A small study gave sepsis patients a combo of two drugs—ulinastatin and thymosin‑alpha‑1—and saw better survival (78% vs 60%) and faster recovery of immune and blood‑clotting markers, but the research was done on very sick hospital patients, not healthy people.

To study the effect of immunomodulatory therapy with ulinastatin plus thymosin alpha( 1) on septic patients. A total of 56 sepsis patients were randomized into a treatment group, receiving immunomodulatory therapy, and a placebo group, a placebo. Acute Physiology and Chronic Health Evaluation II scores, clinical data, lymphocyte subsets, immunological indexes, and coagulation parameters were determined before admission and on the 3rd, 8th, and 28th day after admission to the Intensive Care Unit. The treatment group experienced a 78% cumulative survival, the placebo group experienced a 60% cumulative survival; the survival difference was mirrored by Acute Physiology and Chronic Health Evaluation II scores and more quickly improved leukocyte counts, lymphocyte counts, coagulation parameters, and cytokine levels in the treatment. Combined immunomodulatory therapy with ulinastatin plus thymosin alpha(1) appears to yield improved survival for patients with sepsis; this finding should be verified in larger clinical trials.