Effect of synthetic thymic humoral factor (THF-gamma 2) on T cell activities in immunodeficient ageing mice.
Goso. C C; Frasca. D D; Doria. G G
Key Findings
- Nanogram doses of THF‑gamma 2 restored T‑cell responsiveness in aged, immunodeficient mice
- THF‑gamma 2 increased cytokine‑producing and helper T‑cell activity in a dose‑dependent manner
- Thymosin‑alpha‑1 was 400‑fold less potent than THF‑gamma 2 and eight‑fold less potent than thymopentin
Practical Outcomes
- For biohackers, thymosin‑alpha‑1 may not be the most efficient immune‑boosting peptide; other thymic peptides like thymopentin or THF‑like compounds appear far more potent in animal models. However, human dosing and safety are untested, so any protocol would be experimental and should be approached with caution.
Summary
In old mice with weak immune systems, a tiny amount of a synthetic thymic hormone (THF‑gamma 2) boosted T‑cell activity back to youthful levels, and it worked far better than thymosin‑alpha‑1, which needed much higher doses for a modest effect.
Abstract
Immunodeficient ageing (C57BL/10 x DBA/2)F1 mice were treated by a single injection of synthetic thymic hormones and 4 days later their thymus and spleen cells were assayed in vitro for T cell activities. A few nanograms of THF-gamma 2 were found to raise the frequency of mitogen-responsive T cells in thymus and spleen cell populations as well as the frequency of cytokine-producing splenic T cells, up to the levels observed in young mice. Moreover, injection of THF-gamma 2 was found to restore T cell growth factor (TCGF) production by mitogen-stimulated spleen cells. Also, the helper activity of spleen cells was enhanced by this treatment and increased with increasing the THF-gamma 2 dose over a wide range. Similarly, the effects of thymopentin and thymosin-alpha 1 on T helper cell activity increased with increasing the injected dose, but the efficiencies of THF-gamma 2 and thymopentin were, respectively, 400-fold and eight-fold greater than that of thymosin-alpha 1.
Study Information
pubmed
1992
1992-03-01T00:00:00.000Z
10.1111/j.1365-2249.1992.tb03000.x
30
83