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Thymosin-alpha-1

Thymalfasin, Zadaxin, Thymosin α1

Quick Stats
Studies 759
Trials 63
Overview Studies Clinical Trials
Score 2
1989 pubmed 4 citations

Thymic hormones and prostaglandins. I. Lack of stimulation of prostaglandin production by thymic hormones.

Homo-Delarche. F F; Bach. J F JF; Dardenne. M M

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Key Findings

  • Thymosin‑alpha‑1 (1‑10 µg/ml) did not alter PGE2, 6‑keto‑PGF1α, PGF2α or TXB2 production in spleen cells.
  • Other thymic extracts and peptides (thymosin fraction 5, thymulin, thymopoietin II, TP5) also showed no effect on prostaglandin output.
  • The results do not support the idea that prostaglandins mediate the biological activity of thymic hormones.

Practical Outcomes

  • For biohackers using thymosin‑alpha‑1, there’s no need to pair it with drugs that affect prostaglandins (like NSAIDs) to boost its effect. Focus on other known pathways and dosing guidelines rather than expecting prostaglandin‑related benefits.

Summary

The study tested whether thymosin‑alpha‑1 and other thymic peptides boost the body’s prostaglandin production, which could explain some of their effects. In mouse spleen cells, none of the peptides changed prostaglandin levels, so prostaglandins are likely not the way these hormones work.

Abstract

Prostaglandins (PGs) have been implicated as possible mediators of the biological activity of thymic hormones. It has been shown that type E-PGs are able to mimic the action of several thymic hormones and that indomethacin prevents in vivo or in vitro the appearance of Thy-1+ antigen induced by some of these factors. We thus investigated a possible role for PGs in the mechanism of action of different thymic extracts and peptides. Attempts to modulate prostaglandin production showed that neither thymosin fraction 5 (0.01-100 micrograms/ml), nor thymosin alpha 1 (1-10 micrograms/ml), thymulin (0.001-100 ng/ml), thymopoietin II (10-1000 ng/ml) or TP5 (10-1000 ng/ml) affect PGE2, 6-keto-PGF1 alpha, PGF2 alpha and TXB2 production by spleen cells from control and thymectomized mice. These results do not support the hypothesis that prostaglandins could act as mediators of thymic hormones.

Study Information

Provider

pubmed

Year

1989

Date

1989-08-01T00:00:00.000Z

DOI

10.1016/0090-6980(89)90081-6

Citations

4

References

26