[The effect of thymosin fraction 5 and its synthetic component thymosin-alpha 1 on rat open-field behavior].
Boldyrev. A M AM; Orbachevskaia. I Iu IIu; Mitrokhina. S S SS
Key Findings
- Intracerebroventricular 10 ng of either peptide cut motor activity by ~30 minutes
- Intraperitoneal thymosin fraction 5 (0.15‑0.6 mg/kg) suppressed activity for >2 hours, dose‑dependent
- Both peptides acted similarly regardless of administration route
Practical Outcomes
- These results suggest that thymosin‑alpha‑1 can have sedating effects at certain doses in animals. For human users, high doses might cause fatigue or reduced activity, so start low and monitor energy levels. The study does not provide direct guidance for longevity or performance protocols.
Summary
In rats, both natural thymosin fraction 5 and the synthetic peptide thymosin‑alpha‑1 reduced movement, especially when given by injection into the brain or at higher doses by injection into the body. The effect lasted about half an hour for low brain doses and over two hours for higher body doses.
Abstract
The effect of thymosin fraction 5 and its synthetic component thymosin-alpha 1 administered i. p. and i. c. v. on the behavior of 219 Wistar rats in the open field was studied to establish the effective dose and time of action of both substances. It was shown that at i. c. v. administration of both compounds in a dose of 10 ng the motor activity was suppressed for about 0.5 hour. At i. p. administration thymosin fraction 5 in doses of 0.15, 0.3 and 0.6 mg/kg suppressed the motor activity for more than 2 hours. The higher the dose, the greater the degree of suppression of the motor activity. Both peptides influence in a similar way the motor activity of the animals irrespective of the route of administration.
Study Information
pubmed
1990