[Characteristics of secondary immunologic deficiency in children with chronic hepatitis B and the methods of its correction].
Gol'zand. I V IV; Egorov. V B VB; Popova. I A IA
Key Findings
- Children with chronic hepatitis B often show impaired immune cells and auto‑lymphocytotoxins.
- Thymalin was effective only in patients lacking cold auto‑lymphocytotoxins or with low activity of them.
- Combined therapy with decaris and prednisolone helped children with a strong autoimmune component.
Practical Outcomes
- For most biohackers, this research offers little direct use. It suggests thymalin might help specific immune issues in hepatitis B, but the findings are limited to a pediatric disease context and don’t translate into general longevity or performance protocols.
Summary
The study looked at kids with chronic hepatitis B who had weak immune systems and tested a drug called thymalin. It found that many of these children had problems with immune cells and specific auto‑toxic reactions, and that thymalin helped some but not all cases, depending on the type of auto‑toxins present.
Abstract
A study was made of the immune system of patients with chronic HB-viral infection who showed the signs of secondary immundeficiency. The high frequency of the impairment of immunocompetent cells seen in chronic hepatitis B was established as was the appearance of different-temperature autolymphocytotoxins in response to the infection of mono-nuclears in all the disease stages. The treatment with thymalin proved effective in patients with the lack of cold autolymphocytotoxins or in those with low activity of the latter ones. The combined treatment (decaris plus prednisolone) turned out effective in children with a pronounced autoimmune component of the process (the presence of cold autolymphocytotoxins). It has been shown that the discovered interrelations between the different components of the immune system are conductive to the determination of the pathological process type and the choice of adequate therapy.
Study Information
pubmed
1989