Thymosin beta 10, a new analog of thymosin beta 4 in mammalian tissues.
Erickson-Viitanen. S S; Ruggieri. S S; Natalini. P P; Horecker. B L BL
Key Findings
- Thymosin beta 10 is a 42‑amino‑acid peptide with about 75% similarity to thymosin beta 4.
- It is found together with thymosin beta 4 in spleen, liver, thymus, and several cell lines across multiple species.
- In the spleen of rats, mice, cats, and humans it makes up roughly 0.02% of total protein.
Practical Outcomes
- At this stage there are no actionable protocols, dosing guidelines, or performance benefits to apply. The finding is mainly of scientific interest and may become relevant if future research uncovers functional effects.
Summary
Scientists found a new peptide called thymosin beta 10 that is similar to the well‑known thymosin beta 4. It is present in many animal tissues at very low levels, but the study only describes its structure and where it’s found, not what it does or how to use it.
Abstract
A new analog of thymosin beta 4 has been isolated from tissues of several mammalian species. This peptide, designated thymosin beta 10, is composed of 42 amino acid residues and shows 75% sequence homology with thymosin beta 4. It occurs together with thymoxin beta 4 in a variety of tissues including spleen, liver, and thymus and also in several cultured cell lines. In the spleen of rat, mouse, cat, and man, the new peptide accounts for approximately 0.02% by weight of the total protein. In the calf it is replaced by another homologous peptide, designated thymosin beta 9, whose structure has been reported.
Study Information
pubmed
1983
1983-09-01T00:00:00.000Z
10.1016/0003-9861(83)90047-4
78
6