Completed
PHASE1
INTERVENTIONAL
NCT04311424
Study of Tirzepatide in Healthy Participants
View on ClinicalTrials.gov
Updated Dec 15, 2025
Brief Summary
The purpose of this study is to look at how much tirzepatide gets into the bloodstream and how long the body takes to get rid of it. This study will involve a single dose of 14C radiolabelled tirzepatide. This means that a radioactive tracer substance, C14, will be incorporated into the study drug to investigate the study drug and its breakdown products and to find out how much of these pass from blood into urine, feces and expired air. Screening is required within 28 days prior to the start of the study. For each participant, the total duration of the clinical trial will be approximately 15 weeks, including screening.
Interventions
Name:
14C Tirzepatide
Type:
DRUG
Description:
Administered SC.
Primary Outcomes
Measure:
Urinary Excretion of Tirzepatide Radioactivity Over Time Expressed As A Percentage of the Total Radioactive Dose Administered
TimeFrame:
Pre-dose and up to 63 days post-dose
Description:
Urinary Excretion of Tirzepatide Radioactivity Over Time Expressed As A Percentage of the Total Radioactive Dose Administered.
Measure:
Fecal Excretion of Tirzepatide Radioactivity Over Time Expressed As A Percentage of the Total Radioactive Dose Administered
TimeFrame:
Pre-dose and up to 63 days post-dose
Description:
Fecal Excretion of Tirzepatide Radioactivity Over Time Expressed As A Percentage of the Total Radioactive Dose Administered.
Trial Information
NCT ID
NCT04311424
Status
Completed
Study Type
INTERVENTIONAL
Phases
PHASE1
Sponsor
Eli Lilly and Company
Last Updated
December 15, 2025