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Tirzepatide

Mounjaro, Zepbound, LY3298176

Quick Stats
Studies 183
Trials 100
Completed PHASE4 INTERVENTIONAL NCT06533527

Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

To assess whether holding incretin-based therapy before endoscopy reduces the likelihood of clinically relevant Residual Gastric Volume (RGV). Primary Outcomes: * Residual gastric volume that precludes adequate endoscopic examination * Residual gastric volume that necessitates premature termination of the endoscopy procedure * Need for endotracheal intubation due to stomach contents. * Occurrence of aspiration events requiring extended observation/monitoring, unplanned therapeutics, and/or hospital admission Secondary Outcomes: * Presence of any solid food * Presence of moderate liquid content * Increased RGV(Residual Gastric Volume) defined as any amount of solid content or \> 0.8 mL/Kg of fluid content (measured from the aspiration/suction canister). * Differences in primary and secondary outcomes between different medications

Interventions

Name: GLP-1 medication
Type: DRUG
Description: Continue taking GLP-1 as normally scheduled prior to endoscopy.

Primary Outcomes

Measure: Presence of RGV (Residual Gastric Volume) in Stomach
TimeFrame: Procedure
Description: Residual gastric volume (RGV) that precludes adequate endoscopic examination
Measure: Tracking the Use of Intubation Due to RGV
TimeFrame: Procedure
Description:
Measure: Aspiration Events Due to RGV (Residual Gastric Volume)
TimeFrame: Procedure
Description: Occurrence of aspiration events requiring extended observation/monitoring, unplanned therapeutics, and/or hospital admission

Trial Information

NCT ID

NCT06533527

Status

Completed

Study Type

INTERVENTIONAL

Phases

PHASE4

Sponsor

The Cleveland Clinic

Last Updated

December 15, 2025