Not Yet Recruiting
OBSERVATIONAL
NCT06856928
Impact of Antiobesity Medications on Appetite and Appetite-related Hormones and Metabolites.
View on ClinicalTrials.gov
Updated Dec 15, 2025
Brief Summary
This study aims to explore how anti-obesity medications (AOMs) like semaglutide and tirzepatide affect appetite and energy intake. Researchers will examine two groups: one just starting AOMs and another that has already achieved significant weight loss and maintained it. By conducting meal challenges at different stages of medication use, the study will assess feasibility of the methods and gather preliminary data to design a larger, future study.
Interventions
Name:
Meal Challenge
Type:
OTHER
Description:
The meal challenge scheduled for 4-6 days after the patient's last injection. The study team will insert an indwelling venous catheter into the participant's forearm for serial blood draws. Immediately prior to the meal, participants will consume 1500 mg of acetaminophen (off-label) to facilitate the analysis of gastric emptying. The participant will then begin the meal challenge by eating the test meal, a breakfast casserole, containing 33% of their current resting energy expenditure needs estimated by Mifflin-ST Jeor equation with a composition of 50% carbohydrate, 30% fat and 20% protein. Participants must completely consume the test meal within 25 minutes of initiating the meal. Participants will fill out behavioral questionnaires after consuming the test meal. After the 2-hour blood draw period, participants will be dismissed. Blood will be drawn prior to the meal and at 5, 10, 15, 30, 60, 90, and 120 minutes after initiating the meal.
Primary Outcomes
Measure:
Participant Recruitment
TimeFrame:
6-10 weeks
Description:
Number of participants recruited for the study.
Measure:
Meal test tolerability
TimeFrame:
6-10 weeks
Description:
Number or participants able to tolerate and complete the test meal.
Measure:
Rate of protocol completion
TimeFrame:
6-10 weeks
Description:
Percentage of participants enrolled that complete the protocol
Trial Information
NCT ID
NCT06856928
Status
Not Yet Recruiting
Study Type
OBSERVATIONAL
Sponsor
University of Colorado, Denver
Last Updated
December 15, 2025