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Tirzepatide

Mounjaro, Zepbound, LY3298176

Quick Stats
Studies 183
Trials 100
Completed NA INTERVENTIONAL NCT06895408

Separate and Combined Extrapancreatic Effects of GIP and GLP-1

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

The two gut-derived hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are secreted from intestinal cells in relation to a meal and increase insulin secretion from the pancreas. The hormones also exert effects outside the pancreas, but especially for GIP, these are poorly investigated. Because of this, only GLP-1 based drugs (GLP-1 receptor agonists) are on the market for the treatment of type 2 diabetes and obesity. Nonetheless, a new drug is in clinical development: a combined GIP-GLP-1-receptor agonist (tirzepatide), which has shown better results than GLP-1 alone. The mechanism behind these impressive effects are unknown and in this study, the investigators will look into the exptrapancreatic effects of GIP and GLP-1, separate and combined and thus elucidate the mechanisms of action of this new drug class.

Interventions

Name: Intravenous Infusion
Type: OTHER
Description: Glucose-dependent Insulinotropic Polypeptide
Name: Intravenous Infusion
Type: OTHER
Description: Glucagon-Like Peptide 1
Name: Intravenous Infusion
Type: OTHER
Description: Glucose-dependent Insulinotropic Polypeptide and Glucagon-Like Peptide 1
Name: Intravenous Infusion
Type: OTHER
Description: Saline

Primary Outcomes

Measure: Plasma glucose
TimeFrame: Up to two months
Description: Changes in plasma levels of glucose between interventions assessed through frequently blood sampling during the experimental days
Measure: Plasma glucagon
TimeFrame: Up to two months
Description: Changes in plasma levels of glucagon (gut-derived) between interventions assessed through frequently blood sampling during the experimental days
Measure: Plasma Insulin/C-peptide
TimeFrame: Up to two months
Description: Changes in plasma levels of insulin/C-peptide between interventions assessed through frequently blood sampling during the experimental days
Measure: Plasma triglycerides
TimeFrame: Up to two months
Description: Changes in plasma triglycerides between interventions assessed through frequently blood sampling during the experimental days
Measure: Plasma CTX
TimeFrame: Up to two months
Description: Changes in CTX between interventions assessed through frequently blood sampling during the experimental days
Measure: Plasma PINP
TimeFrame: Up to two months
Description: Changes in plasma PINP between interventions assessed through frequently blood sampling during the experimental days

Trial Information

NCT ID

NCT06895408

Status

Completed

Study Type

INTERVENTIONAL

Phases

NA

Sponsor

University Hospital, Gentofte, Copenhagen

Last Updated

December 15, 2025