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Tirzepatide

Mounjaro, Zepbound, LY3298176

Quick Stats
Studies 183
Trials 100
Not Yet Recruiting PHASE4 INTERVENTIONAL NCT07096908

Tirzepatide Use in People With Obesity and Type 1 Diabetes

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

Tirzepatide, a gut hormone-based medication, has shown promising results in treating obesity, with \~22% weight loss and mild side effects. However, patients with type 2 diabetes typically experience only about 15% weight loss with tirzepatide, despite tolerating the medication well. Its effects in people with both obesity and type 1 diabetes remain largely unknown. Although tirzepatide is not approved for glycemic control in type 1 diabetes, it is licensed for obesity treatment in Gulf and Europe. In Kuwait, more than a quarter of people with type 1 diabetes also have obesity, presenting a unique opportunity to study tirzepatide's impact. This randomized, double-blind controlled trial will evaluate the safety and efficacy of tirzepatide in patients with type 1 diabetes and obesity, comparing usual care with the maximum tolerable dose of tirzepatide to assess its impact on weight loss. The findings may help address important safety concerns and have the potential to inform and influence future clinical practice.

Interventions

Name: Tirzepatide
Type: DRUG
Description: weekly injections
Name: Placebo
Type: DRUG
Description: weekly injections

Primary Outcomes

Measure: Bodyweight
TimeFrame: 76 weeks
Description: Percent body weight change (%)

Trial Information

NCT ID

NCT07096908

Status

Not Yet Recruiting

Study Type

INTERVENTIONAL

Phases

PHASE4

Sponsor

Dasman Diabetes Institute

Last Updated

December 15, 2025