Completed
NA
INTERVENTIONAL
NCT06875687
Prostaglandin Analog Eyelash Serum and Ocular Surface Health: A Prospective Study
View on ClinicalTrials.gov
Updated Dec 15, 2025
Brief Summary
This prospective interventional study investigates the effects of a prostaglandin analog-based eyelash serum on ocular surface integrity, tear film stability, and eyelash growth over six weeks. Nineteen healthy female participants applied the serum daily, with clinical assessments performed at baseline and post-treatment. The study adhered to ethical guidelines, and parameters such as tear film stability, tear volume, ocular hyperemia, and eyelash characteristics were evaluated.
Interventions
Name:
Prostaglandin Analog-Based Eyelash Serum
Type:
OTHER
Description:
This intervention consists of a prostaglandin analog-based eyelash serum applied once daily to the upper eyelid margin for six weeks. The serum contains dechloro dihydroxy difluoro ethylcloprostenolamide (DDDE), a prostaglandin analog known to promote eyelash growth. The formulation also includes panax ginseng root extract, urtica dioica extract, panthenol, niacinamide, and biotinoyl tripeptide-1, which contribute to hair follicle nourishment. The study evaluates its effects on ocular surface integrity, tear film stability, and eyelash growth.
Primary Outcomes
Measure:
Change in Tear Film Stability (A-NIBUT) After Six Weeks of Eyelash Serum Application
TimeFrame:
Baseline and after six weeks of serum application
Description:
Assessment of average non-invasive tear break-up time (A-NIBUT) as an indicator of tear film stability before and after six weeks of daily prostaglandin analog-based eyelash serum application. A-NIBUT is measured using the Firefly S390I slit lamp (MediWorks, Suzhou, China), with lower values indicating increased tear film instability.
Trial Information
NCT ID
NCT06875687
Status
Completed
Study Type
INTERVENTIONAL
Phases
NA
Sponsor
University of Seville
Last Updated
December 15, 2025