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Triptorelin

Decapeptyl, Trelstar, Gonapeptyl, Pamorelin

A synthetic GnRH agonist decapeptide that suppresses gonadotropin and sex hormone production for treating prostate cancer, endometriosis, and precocious puberty.

Molecular Profile
Formula C64H82N18O13
Mol. Weight 1311.45 g/mol
Sequence Gly-Glu-Pro-Pro...
Clinical Data Trials
Scientific Data Studies
Route
Subcutaneous (SC)
100 mcg
SUB
Intramuscular (IM)
3.75 mg every 4 weeks
INT
Intravenous (IV)
0.5 mg
INT

How It Works

How It Works: Triptorelin is a GnRH agonist that binds to receptors in the pituitary gland, causing an initial surge in LH and FSH followed by downregulation and suppression of gonadotropin secretion, leading to reduced sex hormone levels.

  • Binds with high affinity to GnRH receptors on pituitary gonadotroph cells.
  • Induces initial flare-up effect with transient increase in LH, FSH, and downstream sex steroids.
  • Continuous administration leads to receptor desensitization and downregulation.
  • Results in profound suppression of gonadal hormone production, mimicking chemical castration.

Pairs Well With

TB
TB-500
Systemic repair
Cu
GHK-Cu
Skin & collagen
KP
KPV
Anti-inflammatory
Ip
Ipamorelin
GH secretagogue

Latest Clinical Trials

Completed NCT01206803

Ovarian Response Prediction in In Vitro Fertilization (IVF) Patients

University Hospital Schleswig-Holstein
OBSERVATIONAL
Updated Dec 15, 2025
Completed PHASE3 NCT00751790

Efficacy and Safety of a Triptorelin 6-month Formulation in Patients With Advanced Prostate Cancer

Debiopharm International SA
INTERVENTIONAL
Updated Dec 15, 2025
Unknown PHASE4 NCT02825290

Modified Luteal Support for Frozen-Thawed Embryo Transfer - A Prospective Study

Sheba Medical Center
INTERVENTIONAL
Updated Dec 15, 2025
View All Clinical Trials

Latest Studies

Utility 3
pubmed Dec 3, 2025

A retrospective analysis of spontaneous reports of suspected adverse drug reactions to triptorelin acetate in a tertiary pediatric medical center: still a lot of preventable harm.

Cao. Zhongqiang Z; Cheng. Junjie J; Chen. Zebin Z; Lei. Xi X; Yang. Ling L; Zhan...

The study looked at 38 kids who got triptorelin and had bad reactions, mainly skin problems and serious allergic reactions that happened quickly after the shot. Some severe cases were linked to a change in how the drug was made, showing that even small manufacturing tweaks can cause trouble. The authors suggest testing skin reactions before switching brands to avoid life‑threatening allergies.

Utility 2
pubmed Oct 23, 2025

Efficacy of Huayu Xiaozheng decoction combined with triptorelin and mifepristone in the treatment of uterine fibroids and its effect on uterine artery hemodynamics.

Zhou. Yuru Y; Liu. Xinyuan X; Yang. Xiaotian X; Yu. Yaxin Y; Zhou. Yue Y; Zhou....

Adding the Chinese herbal mix Huayu Xiaozheng decoction to the standard drugs triptorelin and mifepristone helped women with uterine fibroids shrink their tumors a bit more, improve blood flow in the uterus, and experience fewer side‑effects, though the drop in fibroid comeback after a year wasn’t statistically clear.

Utility 3
pubmed Oct 15, 2025

Treatment of aggressive prostate cancer with triptorelin in real life in France: the TALISMAN study.

Lebret. Thierry T; Crehange. Gilles G; Pello-Leprince-Ringuet. Nathalie N; Perro...

In France, men with aggressive prostate cancer who start the hormone drug triptorelin usually stick with it for a full year, especially when doctors choose a 3‑month injection based on guidelines and tumor grade. Most patients keep taking the drug continuously, and the safety profile is as expected, with no surprise side effects, though sexual function tends to worsen.

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