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Triptorelin

Decapeptyl, Trelstar, Gonapeptyl, Pamorelin

Quick Stats
Studies 178
Trials 100
Unknown PHASE4 INTERVENTIONAL NCT01353846

Comparison Between Natural and Artificial Cycle in Recipient Oocyte Patients

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

The purpose of this study is to compare the natural cycle (without any medication) with the well-established artificial cycle in an egg donation program.

Detailed Description

Oocyte donation is an assisted reproduction technique well established. In patients with ovarian function, it is necessary to synchronize the cycle of the egg donor with the recipient, usually through endometrial preparation of the recipient by artificial cycle, by administering a GnRH agonist on day 21 of cycle and then administered increasing doses of estrogen therapy to achieve adequate endometrial thickness. The necessity of synchronization between donors and recipient, has made possible not routinely the natural cycle for oocyte donation. The investigators have recently introduced oocyte vitrification and it allows us to plan the egg donation in a different way. Now the investigators can previously cryopreserved donor oocytes and at the time that the investigators have a compatible receiver, then, plan the donation In this study it will be possible compare the results of oocyte donation cycles in terms of pregnancy rate, implantation and liveborn, depending on whether the recipient has made an artificial cycle of preparation endometrial or a natural cycle.

Interventions

Name: observation natural cycle
Type: OTHER
Description: The patients natural reproductive cycle will be observed and compared to the second arm.
Name: Agonist GnRH; estradiol Valerate; progesterone
Type: DRUG
Description: Medications: Agonist GnRH Acetate Triptoreline and Acetate Triptorelina and Estradiol Valerate and Natural micronized progesterone, 400 mg/12 hours vaginal administration

Primary Outcomes

Measure: Preparation and treatment for Assisted Human Reproduction procedures and in the case opf pregnancy, follow up.
TimeFrame: 12 months
Description: Outcome of the study is measured by the pregnancy rates after IVF treatments of both arms.

Trial Information

NCT ID

NCT01353846

Status

Unknown

Study Type

INTERVENTIONAL

Phases

PHASE4

Sponsor

Instituto Valenciano de Infertilidad, IVI VALENCIA

Last Updated

December 15, 2025