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Vesugen

KED, Lys-Glu-Asp tripeptide

A synthetic tripeptide bioregulator that supports vascular health by modulating gene expression in endothelial cells to promote proliferation and repair.

Molecular Profile
Formula C15H26N4O8
Mol. Weight 390.39 g/mol
Sequence Gly-Glu-Pro-Pro...
Clinical Data Trials
Scientific Data Studies
Route
Subcutaneous (SC)
500-2000 mcg daily
SUB
Oral
500-2000 mcg daily
ORA

How It Works

How It Works: Vesugen functions as a bioregulator peptide that modulates gene expression in vascular endothelial cells, promoting cell proliferation and protecting against age-related vascular decline.

  • Epigenetic regulation: Interacts with promoter regions of the Ki-67 gene to enhance cell division and proliferation.
  • Gene expression modulation: Normalizes endothelin-1 expression and increases sirtuin-1 (SIRT-1) levels in endothelial cells.
  • Vascular protection: Supports endothelial function, improves microcirculation, and exhibits potential neuroprotective effects by restoring synaptic plasticity.

Pairs Well With

TB
TB-500
Systemic repair
Cu
GHK-Cu
Skin & collagen
KP
KPV
Anti-inflammatory
Ip
Ipamorelin
GH secretagogue

Latest Clinical Trials

Completed PHASE2 NCT03155100

Carfilzomib + Elotuzumab + Dexamethasone for Relapsed Multiple Myeloma After 1-3 Prior Treatment Lines

Raija Silvennoinen
INTERVENTIONAL
Updated Dec 15, 2025
View All Clinical Trials

Latest Studies

Utility 3
pubmed Oct 22, 2024

Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes.

Kraskovskaya. Nina N; Linkova. Natalia N; Sakhenberg. Elena E; Krieger. Daria D;...

A lab study found that three tiny protein fragments—EDR, KED, and AEDG—help brain cells made from older skin cells grow more branchy dendrites, and the EDR fragment also lowered DNA damage from oxidation. These effects were seen in a dish, not in living people, and the peptides didn’t change mitochondrial or lysosomal activity or the aging marker p16.

Utility 1
pubmed May 12, 2020

Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides.

Ashapkin. Vasily V; Khavinson. Vladimir V; Shilovsky. Gregory G; Linkova. Natali...

In lab-grown human stem cells, three tiny protein fragments (AED, KED, KE) changed the activity of several genes linked to aging, growth, and stress response. The changes depended on how the cells were aged and the specific peptide used, but all were seen at very low (nanomolar) concentrations.

Utility 2
pubmed Dec 10, 2017

Spontaneous death of rat chloroleukaemia cells induced by an endogenous growth inhibitor.

Rytömaa. T T; Grip-Rytömaa. K K

Researchers re‑examined old data and think a tiny protein fragment (pyroGlu‑Glu‑Asp‑Cys‑Lys) made by rat leukemia cells can cause those cells to kill themselves in a way that’s different from normal cell‑death processes. The peptide seems to be secreted by the cancer cells themselves and might be linked to a natural anti‑cancer mechanism, but the work is limited to a specific rat cell line and hasn’t been tested in humans.

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