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KED, Lys-Glu-Asp tripeptide
A synthetic tripeptide bioregulator that supports vascular health by modulating gene expression in endothelial cells to promote proliferation and repair.
Kitachev. K V KV; Sazonov. A B AB; Kozlov. K L KL; Petrov. K Iu KIu; Sliusarev. A S AS; Khavinson. V...
A small study gave the peptide Vezugen to 41 older men with erectile dysfunction caused by poor blood flow. After treatment, blood flow in the main penile artery improved, and the men reported better erectile function.
Kraskovskaya. Nina N; Linkova. Natalia N; Sakhenberg. Elena E; Krieger. Daria D; Polyakova. Victoria...
A lab study found that three tiny protein fragments—EDR, KED, and AEDG—help brain cells made from older skin cells grow more branchy dendrites, and the EDR fragment also lowered DNA damage from oxidation. These effects were seen in a dish, not in living people, and the peptides didn’t change mitochondrial or lysosomal activity or the aging marker p16.
Myakotnykh. V S VS; Torgashov. M N MN; Egorin. K V KV; Meshchaninov. V N VN; Gavrilov. V I VI; Borov...
A study of 110 people compared several anti‑aging tricks, including dry CO₂ baths, hyperbaric oxygen, massage, and two peptide mixes called Vezugen and Pinealon. The biggest drop in biological‑age markers came when both peptide mixes were taken together, and they were also among the safest options. Massage was also safe, while CO₂ baths and hyperbaric oxygen helped but have more safety limits.
Khavinson. V Kh VKh; Lin'kova. N S NS; Evlashkina. E V EV; Durnova. A O AO; Kozlov. K L KL; Gutop. O...
A study found that two short peptides, T‑38 and RR‑1, can make blood‑vessel cells grow more and look less stressed in lab dishes, and they also lower a molecule (E‑selectin) that helps build artery‑clogging plaques. This suggests they might protect arteries, but the work is only in cells, not people.
Kozlov. K L KL; Bolotov. I I II; Linkova. N S NS; Drobintseva. A O AO; Khavinson. V Kh VK; Dyakonov....
The study shows that the tiny peptide KED (Lys‑Glu‑Asp) can help blood vessel cells behave more normally in lab dishes, lowering a harmful molecule (endothelin‑1), fixing cell‑to‑cell connections, and boosting a longevity‑related protein (sirtuin‑1).
Kozina. L S LS
The study found that short peptides like vesugen can help protect the body against low‑oxygen conditions, but the effect is modest compared to a peptide called pinealon. The protection seems to come from boosting the body's own antioxidant enzymes rather than just blocking harmful molecules.
Jing. Jian J
Researchers made a small circular protein that includes a Lys‑Gly‑Asp (KGD) piece and found it can strongly stop platelets from clumping together by attaching to a specific platelet receptor. The work is still at the lab‑test stage, with no human data or dosing information yet.
Rytömaa. T T; Grip-Rytömaa. K K
Researchers re‑examined old data and think a tiny protein fragment (pyroGlu‑Glu‑Asp‑Cys‑Lys) made by rat leukemia cells can cause those cells to kill themselves in a way that’s different from normal cell‑death processes. The peptide seems to be secreted by the cancer cells themselves and might be linked to a natural anti‑cancer mechanism, but the work is limited to a specific rat cell line and hasn’t been tested in humans.
Chalisova. N I NI; Lopatina. N G NG; Kamishev. N G NG; Linkova. N S NS; Koncevaya. E A EA; Dudkov. A...
The study shows that the three‑amino‑acid peptide Lys‑Glu‑Asp can make certain brain and hormone cells grow faster and die less in lab dishes, especially in tissue from older animals, and it even helps bees learn better, but it’s all done in cell cultures, not people.
Bashkireva. A S AS; Artamonova. V G VG
A study of truck drivers versus metal workers found that drivers had more anxiety, depression, and borderline mental issues, likely due to long hours and job stress. Giving them a mix of two peptides (pinealon and vesugen) improved mood, reduced stress symptoms, and lowered the chance of developing these mental problems. The biggest benefit was seen when both peptides were used together, but the research didn’t give clear dosing or safety details.
Kozina. L S LS; Arutiunian. A V AV; Stvolinskiĭ. S L SL; Khavinson. V Kh VKh
In lab tests, the short peptide vesugen (along with similar peptides) didn’t act like a classic antioxidant, but it helped keep lipids in human blood particles from breaking down and made red blood cells tougher against swelling. It also raised the normal level of reactive oxygen inside cells while actually lowering the number of dead brain cells, hinting it might influence cell death pathways. However, these results are only from cell‑culture experiments, not real‑world human studies.
Trofimov. A V AV
A short three‑amino‑acid peptide helped repair the lining of the small intestine in older rats that had been damaged by radiation, showing signs of anti‑aging effects in the gut. The study suggests the peptide may improve blood vessel health and boost cell growth in the duodenum, but it was only tested in rats and no human dosing or safety data are available.
Ryzhak. A P AP; Kvetnoĭ. I M IM; Emanuél'. V L VL
In rats that age faster because of radiation, a tiny three‑amino‑acid peptide (Lys‑Glu‑Asp, called T‑38) helped the pancreas repair itself and improve hormone balance. The same kind of age‑related damage was worse in these fast‑aging rats than in normal old rats, but the peptide boosted the organ's natural healing.
Iarilin. A A AA; Khavinson. V Kh VKh; Poliakova. V O VO; Lin'kova. N S NS; Kvetnoĭ. I M IM
A lab study showed that two synthetic peptides, called T-32 and T-38, can help immature immune cells (thymocytes) turn into regulatory T‑cells, which are important for keeping the immune system balanced. The peptides also made these cells grow more and die less, and they boosted the same effects in already‑mature regulatory T‑cells.
Bashkireva. A S AS; Kachan. E Yu EY
The study looked at whether adding tiny protein fragments called "cytogens" to the diet of people who work in tough, hazardous jobs can help them stay healthier and keep their work performance up. They used a questionnaire (the Work Ability Index) to see if these peptides improved the workers' ability to cope with stress and age‑related decline. The authors say the peptides seemed to boost the body's adaptive resources and overall well‑being, but they don’t give details on how much was taken or the exact results.
Khavinson. V Kh VKh; Tarnovskaia. S I SI; Lin'kova. N S NS; Guton. E O EO; Elashkina. E V EV
Researchers found that the short peptide vesugen (and a similar peptide D-7) can boost the activity of a protein called Ki‑67, which helps blood‑vessel cells keep dividing as we age. In lab tests, the peptides attached to a specific DNA region that controls the Ki‑67 gene, suggesting they may turn the gene on more strongly. This could explain why older people who take vesugen sometimes see better blood‑vessel health, but the work was done only in cell cultures and computer models.
Meshchaninov. V N VN; Tkachenko. E L EL; Zharkov. S V SV; Gavrilov. I V IV; Katyreva. Iu E IuE
A tiny study (32 people with multiple health issues and brain syndrome) gave two short synthetic peptides, Vesugen and Pinealon. Both seemed to boost muscle‑like growth and brain activity, and the researchers say they slowed biological aging, with Vesugen looking a bit better. However, they also found Vesugen acted as a pro‑oxidant and reduced certain blood stem cells, hinting at possible safety concerns. No changes were seen in DNA packaging, which the authors call a good sign.
Chalisova. N I NI; Lesnyak. V V VV; Oganezova. E V EV; Rizhak. G A GA
A tiny protein made of three amino acids (Lys-Glu-Asp) helped rat spleen cells keep growing even when a chemotherapy drug that normally stops cell growth was added, but this was only shown in a lab dish with rat tissue, not in people.
Ashapkin. Vasily V; Khavinson. Vladimir V; Shilovsky. Gregory G; Linkova. Natalia N; Vanuyshin. Bori...
In lab-grown human stem cells, three tiny protein fragments (AED, KED, KE) changed the activity of several genes linked to aging, growth, and stress response. The changes depended on how the cells were aged and the specific peptide used, but all were seen at very low (nanomolar) concentrations.