Effect of tripeptide Lys-Glu-Asp on physiological activity of neuroimmunoendocrine system cells.
Chalisova. N I NI; Lopatina. N G NG; Kamishev. N G NG; Linkova. N S NS; Koncevaya. E A EA; Dudkov. A V AV; Kozina. L S LS; Khavinson. V Kh VKh; Titkov. Yu S YS
Key Findings
- Lys‑Glu‑Asp boosts cell proliferation and cuts apoptosis in neuro‑immuno‑endocrine cultures
- The effect is stronger in tissues from old animals, especially in the pineal gland
- It raises markers of immature lymphocytes (CD5) and macrophages (CD68) and improves short‑ and long‑term memory in honey bees
Practical Outcomes
- The peptide hints at possible anti‑aging cellular benefits, but because the data are only from animal tissue cultures and insects, there’s no clear dosage, safety, or protocol for humans yet. Biohackers should view this as early‑stage evidence that needs much more research before practical use.
Summary
The study shows that the three‑amino‑acid peptide Lys‑Glu‑Asp can make certain brain and hormone cells grow faster and die less in lab dishes, especially in tissue from older animals, and it even helps bees learn better, but it’s all done in cell cultures, not people.
Abstract
Tripeptide Lys-Glu-Asp stimulates proliferation and inhibits apoptosis in organotypic cultures of neuroimmunoendocrine system cells. Lys-Glu-Asp accelerates cell renewal processes (decrease of apoptosis marker p53 and increase of proliferation marker Ki-67) in the pineal gland; this effect is more pronounced in cultures derived from old animals than in young cultures. The tripeptide induces the expression of low-differentiated lymphocyte marker CD5 and macrophage marker CD68, but in "old" cultures this effect is less pronounced than in "young" ones. Thus, in tissue culture Lys-Glu-Asp primarily affects the nervous and endocrine tissues during aging and produces a less pronounced effect on the nervous tissue. Physiological activity of the tripeptide consists in modulation of associative learning of honey bee in the model of short-term and the long-term memory.
Study Information
pubmed
2012
2012-08-01T00:00:00.000Z
10.1007/s10517-012-1768-7