Molecular aspects of anti-atherosclerotic effects of short peptides.
Khavinson. V Kh VKh; Lin'kova. N S NS; Evlashkina. E V EV; Durnova. A O AO; Kozlov. K L KL; Gutop. O E OE
Key Findings
- T‑38 and RR‑1 increase Ki‑67, a marker of cell renewal, in vascular cells
- They reduce p53 protein levels, indicating less cellular stress
- They lower E‑selectin production, which could lessen atherosclerotic plaque formation
Practical Outcomes
- These peptides show promise for supporting vascular health, but there’s no human data, dosing guidance, or safety info yet. For now, they’re interesting research leads rather than ready‑to‑use supplements for biohackers.
Summary
A study found that two short peptides, T‑38 and RR‑1, can make blood‑vessel cells grow more and look less stressed in lab dishes, and they also lower a molecule (E‑selectin) that helps build artery‑clogging plaques. This suggests they might protect arteries, but the work is only in cells, not people.
Abstract
We studied molecular mechanisms of the vasoprotective effects of tripeptide T-38 and dipeptide RR-1. Short peptides T-38 and the RR-1 activate the processes of cell renewal in organotypic and dissociated cultures of vascular cells during aging by increasing the expression of Ki-67 and reducing the synthesis of p53 protein. T-38 and RR-1 reduce the synthesis of E-selectin, adhesion molecule involved in the formation of atherosclerotic plaques.
Study Information
pubmed
2014
2014-11-19T00:00:00.000Z
10.1007/s10517-014-2713-8