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Body Protection Compound-157, PL-14736, Pentadecapeptide BPC 157
A synthetic pentadecapeptide derived from human gastric juice that promotes tissue healing, angiogenesis, and cytoprotection across various organs.
Seiwerth. Sven S; Brcic. Luka L; Vuletic. Lovorka Batelja LB; Kolenc. Danijela D; Aralica. Gorana G;...
BPC‑157 appears to be a very powerful agent for fixing damaged blood vessels. It helps the lining of vessels heal, promotes the growth of new vessels, eases swelling, and can lower the chance of clots by working through several natural pathways like nitric oxide and VEGF.
Sikiric. P P; Seiwerth. S S; Brcic. L L; Blagaic. A B AB; Zoricic. I I; Sever. M M; Klicek. R R; Rad...
In rats, the peptide BPC‑157 kept stomach blood vessels intact and stopped damage to the stomach, esophagus, and duodenum when the stomach was stretched and exposed to alcohol. It worked better than common drugs like ranitidine or omeprazole, and also showed benefits for blood‑vessel health, nerve function, and even brain chemistry in animal tests.
Lojo. Nermin N; Rasic. Zarko Z; Zenko Sever. Anita A; Kolenc. Danijela D; Vukusic. Darko D; Drmic. D...
In rats that had most of their small intestine removed, the peptide BPC‑157 (given right after surgery) stopped the severe gut, liver and brain damage that normally gets worse when NSA‑painkillers like diclofenac are taken. Adding L‑arginine helped a bit when the nitric‑oxide system was blocked, but BPC‑157 alone was enough to protect the animals.
Tudor. Mario M; Jandric. Ivan I; Marovic. Anton A; Gjurasin. Miroslav M; Perovic. Darko D; Radic. Bo...
In a mouse study, giving the peptide BPC‑157 before a head blow made the brain injury less severe and helped more mice stay awake and survive for at least a day. Even tiny doses (nanograms per kilogram) worked, and the sooner the peptide was given before the impact, the better the protection.
Sever. Marko M; Klicek. Robert R; Radic. Bozo B; Brcic. Luka L; Zoricic. Ivan I; Drmic. Domagoj D; I...
In rats that had most of their small intestine removed, giving the peptide BPC‑157 (either in the drinking water or by injection) stopped the usual rapid weight loss and actually caused the animals to gain weight. Their gut tissue also healed better, with longer villi, deeper crypts, stronger muscle layers, and tougher connections where the intestine was sewn back together.
Krivic. A A; Majerovic. M M; Jelic. I I; Seiwerth. S S; Sikiric. P P
In rats with a cut Achilles tendon attached to bone, a single daily dose of the peptide BPC‑157 (10 µg/kg) given right after surgery helped the tendon heal faster. It reduced inflammation, boosted new blood‑vessel growth, and led to better movement scores compared to a steroid drug, which only cut inflammation but slowed blood‑vessel formation and didn’t improve function.
Skorjanec. Sandra S; Dolovski. Zdravko Z; Kocman. Ivan I; Brcic. Luka L; Blagaic Boban. Alenka A; Ba...
In a rat study, the peptide BPC‑157 given in drinking water or by injection helped both skin wounds and stomach ulcers heal faster and stronger than common ulcer medicines, even when a steroid drug was used to slow healing.
Sikiric. Predrag P; Seiwerth. Sven S; Rucman. Rudolf R; Turkovic. Branko B; Rokotov. Dinko Stancic D...
The abstract says that the peptide BPC‑157 is very safe and helps heal ulcers, wounds, and many organ injuries. The authors think it could also act like an antidote to the harmful side‑effects of NSAIDs (like aspirin), protecting the stomach, liver, brain and even helping with bleeding problems. All the benefits were seen at very low doses given by mouth or injection.
Seveljević-Jaran. D D; Cuzić. S S; Dominis-Kramarić. M M; Glojnarić. I I; Iv...
A lab-made peptide called PL 14736, taken from human gastric juice, was applied as a gel to full‑thickness skin cuts in rats with high blood sugar. It sped up wound healing in a dose‑dependent way, matching the performance of an FDA‑approved diabetic ulcer drug (becaplermin) by boosting the growth of healthy granulation tissue and collagen, though it didn’t change how much the wound shrank.
Masnec. Sanja S; Kokot. Antonio A; Zlatar. Mirna M; Kalauz. Miro M; Kunjko. Kristian K; Radic. Bozo...
In a rat study, eye drops containing the peptide BPC‑157 helped corneal cuts heal much faster and kept the eye clear, while untreated rats healed slowly and grew new blood vessels in the wound area.
Grgic. Tihomir T; Grgic. Dora D; Drmic. Domagoj D; Sever. Anita Zenko AZ; Petrovic. Igor I; Sucic. M...
In a rat study, the peptide BPC‑157 (a stable 15‑amino‑acid stomach peptide) was given either in the drinking water or by injection after surgically creating a connection between the colon and bladder. Both low‑dose oral (10 µg per kg body weight) and very low‑dose injection (10 µg or even 10 ng per kg) quickly repaired the holes, stopped leakage, and prevented scar tissue and blockages. The treated rats healed fully, while untreated rats kept having leaks and complications.
Sikiric. Predrag P; Seiwerth. Sven S; Rucman. Rudolf R; Kolenc. Danijela D; Vuletic. Lovorka Batelja...
BPC‑157 is a stable 15‑amino‑acid peptide that naturally lives in the stomach. In animal studies and early human trials it looks safe and helps heal ulcers, gut damage, liver, pancreas, and even some brain injuries. It also seems to tweak serotonin and dopamine pathways, which could improve mood, movement, and nerve repair. While the data are promising, the research is still mostly pre‑clinical and doesn’t give clear dosing rules for everyday use.
Duplancic. Bozidar B; Stambolija. Vasilije V; Holjevac. Jadranka J; Zemba. Mladen M; Balenovic. Igor...
In rats and mice, a single tiny dose of the peptide BPC‑157 (as low as 10 pg per kilogram) stopped severe allergic‑like reactions caused by injecting dextran or egg white, and it could also rescue animals that were already reacting. Standard allergy drugs worked only a little, while BPC‑157 alone was much more effective.
Dobric. Ivan I; Drvis. Petar P; Petrovic. Igor I; Shejbal. Drazen D; Brcic. Luka L; Blagaic. Alenka...
In rats that develop long‑lasting throat inflammation because their stomach valve (pyloric sphincter) stops working, giving the peptide BPC‑157 (either by injection, in drinking water, or directly into the stomach) healed the inflammation and restored normal pressure in both the stomach valve and the lower esophageal valve. The same peptide also raised the pressure of the lower esophageal valve in healthy rats while lowering stomach‑valve pressure. A common acid‑blocking drug, ranitidine, did not help.
Petrovic. Igor I; Dobric. Ivan I; Drvis. Petar P; Shejbal. Drazen D; Brcic. Luka L; Blagaic. Alenka...
In a rat study, the peptide BPC‑157 repaired long‑lasting esophagus inflammation and fixed weak stomach and esophageal sphincters. It worked whether given by injection or mixed into drinking water, while the common drug ranitidine did not help.
Blagaic. Alenka Boban AB; Blagaic. Vladimir V; Romic. Zeljko Z; Sikiric. Predrag P
In mice, the peptide BPC‑157 (a tiny 15‑amino‑acid chain) reduced damage to the stomach and liver caused by both a single big dose of alcohol and long‑term drinking. It also lessened alcohol‑withdrawal symptoms when given after the mice stopped drinking. The effects were seen at very tiny doses given by injection or by mouth.
Bilic. M M; Bumber. Z Z; Blagaic. A Boban AB; Batelja. L L; Seiwerth. S S; Sikiric. P P
In a mouse study, putting a tiny amount of the peptide BPC‑157 into a simple cream on skin that was burned by a CO₂ laser helped the wounds heal faster and look better under a microscope. The benefit showed up even at extremely low doses and didn’t need any special carriers or preservatives.
Xue. Xiao-Chang XC; Wu. Yong-Jie YJ; Gao. Ming-Tang MT; Li. Wen-Guang WG; Zhao. Ning N; Wang. Zeng-L...
In rats, the peptide BPC‑157 (a 15‑amino‑acid fragment) helped prevent and heal stomach ulcers. Giving it by injection into muscle worked better than swallowing it, and doses around 400‑800 ng per kilogram reduced ulcer size by roughly half to two‑thirds, even matching or beating a common ulcer drug (famotidine).
Bedekovic. Vlado V; Mise. Stjepan S; Anic. Tomislav T; Staresinic. Mario M; Gjurasin. Miroslav M; Ko...
In rats, the peptide BPC‑157 stopped duodenal ulcers caused by a chemical, even when the animals had their salivary glands removed. Common ulcer drugs (like ranitidine, omeprazole, and atropine) only worked when the salivary glands were intact, showing they need something from saliva to be effective. This suggests BPC‑157 works through a different, saliva‑independent protective pathway.
Mikus. D D; Sikiric. P P; Seiwerth. S S; Petricevic. A A; Aralica. G G; Druzijancic. N N; Rucman. R...
In mice, a cream that contains the peptide BPC‑157 helped skin burns heal faster and stronger, reduced swelling and inflammation, and also protected the stomach from damage that usually follows severe burns. The peptide worked better than the standard silver sulfadiazine cream and even helped when given by injection.