Use search to browse all 100+ peptides
Body Protection Compound-157, PL-14736, Pentadecapeptide BPC 157
A synthetic pentadecapeptide derived from human gastric juice that promotes tissue healing, angiogenesis, and cytoprotection across various organs.
Lee. Edwin E; Burgess. Kailynd K
A tiny pilot study gave two healthy adults an IV dose of BPC‑157 (10 mg one day, 20 mg the next) and found no changes in heart, liver, kidney, thyroid or blood sugar labs and no side effects, suggesting the peptide is well‑tolerated at these levels.
Lee. Edwin E; Padgett. Blake B
A tiny retrospective study looked at 16 people who got a shot of the peptide BPC‑157 (sometimes with another peptide, TB4) directly into their knee. Most reported that their knee pain got a lot better – about 92% with BPC‑157 alone and 75% when both peptides were used, giving an overall relief rate of roughly 88%. The study didn’t use any formal pain scales or imaging, and there was no control group, so the results are very preliminary.
Brcic. L L; Brcic. I I; Staresinic. M M; Novinscak. T T; Sikiric. P P; Seiwerth. S S
The study shows that BPC‑157 helps muscles and tendons heal in animals by boosting the body’s own blood‑vessel growth signals (VEGF). It doesn’t directly cause new vessels in a petri dish, but when given to injured animals it leads to better‑organized blood‑vessel formation and overall healing.
Klicek. R R; Kolenc. D D; Suran. J J; Drmic. D D; Brcic. L L; Aralica. G G; Sever. M M; Holjevac. J...
In rats, the peptide BPC‑157 helped heal severe colon inflammation and surgical wounds, and it also protected brain cells from damage in a model of multiple sclerosis, leading to better movement and strength.
Skorjanec. S S; Kokot. A A; Drmic. D D; Radic. B B; Sever. M M; Klicek. R R; Kolenc. D D; Zenko. A A...
In rats with a serious gut wound (a duodenocutaneous fistula), the peptide BPC‑157 dramatically healed the damage, stopped leaks, restored stomach valve function, and prevented death. It worked whether given by injection or in drinking water, and even over‑rode the harmful effects of a nitric‑oxide blocker. Arginine (a nitric‑oxide precursor) also helped, but not as fast as BPC‑157.
Keremi. B B; Lohinai. Z Z; Komora. P P; Duhaj. S S; Borsi. K K; Jobbagy-Ovari. G G; Kallo. K K; Szek...
In a rat study, daily injections of the peptide BPC‑157 for 12 days didn’t change normal gum blood flow, but it dramatically cut inflammation, fluid leakage, and bone loss caused by experimentally induced gum disease. This suggests the peptide has strong anti‑inflammatory effects in the mouth, at least in animals.
Jelovac. N N; Sikiric. P P; Rucman. R R; Petek. M M; Perovic. D D; Marovic. A A; Anic. T T; Seiwerth...
In a mouse study, giving the peptide BPC‑157 together with the anti‑anxiety drug diazepam stopped the animals from becoming tolerant to the drug and delayed the signs of withdrawal. The peptide seemed to keep the brain's GABA system more stable, which is why the usual loss of drug effect and dependence didn’t happen as quickly.
Sikiric. P P; Petek. M M; Rucman. R R; Seiwerth. S S; Grabarević. Z Z; Rotkvić. I I; Jag...
In rats, a tiny dose of BPC‑157 (10 µg per kg) given by injection protects the stomach from stress‑induced ulcers. This protection stays strong unless the animals have their ovaries removed or their adrenal medulla destroyed, and it weakens when the thyroid and parathyroid glands are taken out. Cutting the vagus nerve, spleen, or testes doesn’t change the effect.
Jung. Young-Hoon YH; Kim. Haekyu H; Kim. Hyaejin H; Kim. Eunsoo E; Baik. Jiseok J; Kang. Hyunjong H
In rats, the peptide BPC‑157 lowered pain right after a skin incision, but the effect was brief and faded after a few days. It helped with the first burst of pain but didn’t reduce the later, inflammation‑driven pain that morphine can affect.
Škrlec. Katja K; Ručman. Rudolf R; Jarc. Eva E; Sikirić. Predrag P; Švajger....
Scientists engineered a friendly gut bacterium (Lactococcus lactis) to make and release the healing peptide BPC‑157. They found that letting the bacteria secrete the peptide gave higher amounts than just sticking it on the cell surface, and the secreted peptide lowered harmful oxidative stress in a lab cell model, hinting it could help gut inflammation.
McGuire. Flynn P FP; Martinez. Riley R; Lenz. Annika A; Skinner. Lee L; Cushman. Daniel M DM
BPC-157 is a lab-made peptide that has shown strong healing effects in animal studies, especially for tendons, muscles, and nerves. In people, only a handful of tiny studies have been done and they reported no side‑effects, but there’s no solid proof it works or is safe for regular use. Until bigger human trials are done, it should be treated as an experimental compound.
DeFoor. Mikalyn T MT; Dekker. Travis J TJ
The abstract talks about injectable peptides like BPC‑157 as a hot new trend for faster recovery and better performance. Early animal studies hint it could help endurance, metabolism, and tissue repair, but there’s almost no solid human research yet. The authors warn that the market is growing fast, the products are unregulated, and doctors need to know the safety, legal, and ethical issues because athletes will keep asking about them.
Szabo. Sandor S; Yoshida. Masashi M; Filakovszky. Janos J; Juhasz. Gyorgy G
The paper reviews 80 years of stress research, highlighting that stress often causes stomach ulcers. It mentions a newer peptide called BPC‑157 that looks promising for preventing or healing these ulcers, but it doesn’t give dosing details or concrete protocols.
Premuzic Mestrovic. Ivica I; Smoday. Ivan Maria IM; Kalogjera. Luka L; Krezic. Ivan I; Zizek. Helena...
In rats, a huge dose of the heart drug sotalol caused massive blood vessel blockages, organ swelling, and brain bleeding. Giving a tiny oral dose of the peptide BPC‑157 shortly after the drug almost completely stopped these damages, protecting the heart, brain, liver, kidneys and blood vessels.
Sikiric. Predrag P; Gojkovic. Slaven S; Krezic. Ivan I; Smoday. Ivan Maria IM; Kalogjera. Luka L; Zi...
The study says that a stable stomach peptide called BPC‑157 helped animals recover from a wide range of problems, from anxiety and seizures to heart failure and organ damage, by apparently fixing the communication between the gut and the brain. However, the paper is mostly animal work, gives no clear dosing guidelines, and the claims are very broad.
Strbe. Sanja S; Smoday. Ivan Maria IM; Krezic. Ivan I; Kalogjera. Luka L; Vukovic. Vlasta V; Zizek....
In rats, a peptide called BPC‑157 quickly fixed severe blood‑vessel and organ damage caused by drugs like antipsychotics, amphetamine, and domperidone. The peptide was given at a tiny dose (about 10 µg per kilogram) right after the harmful drug, and it stopped swelling, bleeding, and clotting in the brain, heart, lungs, liver, kidneys and gut.
Smoday. Ivan Maria IM; Krezic. Ivan I; Kalogjera. Luka L; Vukovic. Vlasta V; Zizek. Helena H; Skoro....
In rats that were given a chemical to block a big vein and cause severe organ damage, a tiny protein called BPC‑157 (given by mouth or injection) quickly helped restore blood flow, reduced clot‑related damage in the lungs, and protected the brain, heart, liver, kidneys and gut. The peptide seemed to open backup blood routes, especially the azygos vein, and lowered dangerous pressure spikes in the veins.
Sikiric. Predrag P; Kokot. Antonio A; Kralj. Tamara T; Zlatar. Mirna M; Masnec. Sanja S; Lazic. Rati...
In a rat study, the peptide BPC‑157 quickly lowered eye pressure in a glaucoma model and helped keep the retina, optic nerve, and cornea healthy. It also reduced related blood‑pressure problems in the brain and other vessels. The results are promising but only in animals, with no human dosing or safety information yet.
Sikiric. Predrag P; Boban Blagaic. Alenka A; Krezic. Ivan I; Zizek. Helena H; Kalogjera. Luka L; Smo...
The paper reviews how dopamine and dopamine‑acting drugs affect stomach ulcer healing and mentions that the peptide BPC‑157 might work as a bridge in this dopamine‑gut connection. It mainly discusses theory and past animal studies, not new human data or dosing instructions.
Józwiak. Michalina M; Bauer. Marta M; Kamysz. Wojciech W; Kleczkowska. Patrycja P
BPC‑157 is a short protein taken from human stomach juice that has shown many helpful effects in animal studies, like healing injuries, helping gut problems, and protecting the brain. It appears to be safe in those studies, but there are almost no human trials, so its real‑world benefits and proper dosing are still unknown.