Modulating Effect of Peptide Therapy on the Morphofunctional State of Bronchial Epithelium in Rats with Obstructive Lung Pathology.
Kuzubova. N A NA; Lebedeva. E S ES; Dvorakovskaya. I V IV; Surkova. E A EA; Plat...
Bronchogen
Ala-Glu-Asp-Leu, AEDL
A synthetic tetrapeptide bioregulator targeting lung tissue to reduce inflammation, promote repair, and modulate gene expression in bronchial cells.
Molecular Profile
Formula
C18H30N4O9
Mol. Weight
446.45 g/mol
Sequence
Gly-Glu-Pro-Pro...
| Route | |
|---|---|
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Subcutaneous (SC)
500 mcg/day
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Oral
1-2 mg/day
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How It Works
How It Works: Bronchogen is a bioregulatory peptide that penetrates lung cells, binds to DNA and chromatin, and modulates gene expression to support respiratory health and tissue regeneration.
- DNA and Histone Binding: Interacts directly with DNA sequences and histones to alter chromatin structure and gene expression.
- Signaling Pathway Activation: Triggers intracellular signaling, such as STAT1 phosphorylation, independent of surface receptors.
- Anti-Inflammatory Effects: Reduces neutrophilic inflammation by normalizing pro-inflammatory cytokines and cell composition in bronchoalveolar fluid.
- Epithelial Restoration: Promotes repair of bronchial epithelium, restores ciliated cells, and enhances surfactant production.
- Geroprotective Action: Upregulates differentiation factors in aging lung cells, counteracting age-related decline.
Latest Clinical Trials
See All Clinical Trials
Completed
NCT00746759
Airway Epithelium Gene Expression: AEGIS IDE
Allegro Diagnostics, Corp.
OBSERVATIONAL
Updated Dec 15, 2025
Unknown
PHASE1
NCT05112159
Study of IPG1094 in Healthy Participants
Nanjing Immunophage Biotech Co., Ltd
INTERVENTIONAL
Updated Dec 15, 2025
Completed
PHASE1
NCT05842798
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TNM002 in Chinese Healthy Adults
Zhuhai Trinomab Pharmaceutical Co., Ltd.
INTERVENTIONAL
Updated Dec 15, 2025
Latest Studies
See All StudiesPeptides tissue-specifically stimulate cell differentiation during their aging.
Khavinson. V Kh VKh; Linkova. N S NS; Polyakova. V O VO; Kheifets. O V OV; Tarno...
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Effect of the peptide bronchogen (Ala-Asp-Glu-Leu) on DNA thermostability.
Monaselidze. J R JR; Khavinson. V Kh VKh; Gorgoshidze. M Z MZ; Khachidze. D G DG...
The study examines ...