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Bronchogen

Ala-Glu-Asp-Leu, AEDL

Quick Stats
Studies 10
Trials 30
Overview Studies Clinical Trials
Score 2
2017 pubmed

[ANTIINFLAMMATORY AND REGENERATIVE EFFECT OF PEPTIDE THERAPY IN THE MODEL OF OBSTRUCTIVE LUNG PATHOLOGY].

Titova. O N ON; Kuzubova. N A NA; Lebedeva. E S ES; Preobrazhenskaya. T N TN; Surkova. E A EA; Dvorakovskaya. I V IV

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Key Findings

  • Bronchogen reduced neutrophil‑driven inflammation and normalized pro‑inflammatory cytokines in the lung fluid.
  • The damaged bronchial epithelium in COPD‑like rats regenerated after peptide treatment.
  • Levels of secretory IgA (a local immunity marker) and surfactant protein B (which reduces alveolar surface tension) increased following therapy.

Practical Outcomes

  • The study shows that bronchogen has anti‑inflammatory and tissue‑repair effects in animal lungs, but it provides no human dosing, safety, or administration guidance. For biohackers, it’s an interesting proof‑of‑concept that may inspire future lung‑health supplements, yet it isn’t ready for direct use or protocol development.

Summary

In a rat model of COPD, a short four‑amino‑acid peptide called bronchogen lowered lung inflammation, helped the airway lining heal, and boosted local immune proteins and a surfactant that keeps the lungs flexible.

Abstract

The effect of the tetrapeptide bronchogen on the structural and functional state of the bronchial epithelium and inflammatory activity in the lungs was studied in the chronic obstructive pulmonary disease (COPD) model, created in rats by a 60-day intermittent exposure to nitrogen dioxide. The cell composition and cytokine-enzyme profile of bronchoalveolar lavage fluid (BALF), the content of secretory immunoglobulin A and surfactant protein B in BALF were determined. Following the course of peptide treatment the decreased activity of neutrophilic inflammation with the normalization of cellular composition and profile of pro-inflammatory cytokines and enzymes in the bronchoalveolar space was observed. The structure of bronchial epithelium, disturbed during formation of COPD model, was restored and accompanied by restoration of its functional activity as evidenced by an increase of secretory immunoglobulin A (local immunity marker) and surfactant protein B, responsible for reducing the alveolar surface tension.

Study Information

Provider

pubmed

Year

2017