Score
3
2000
pubmed
Effect of tetrapeptide cortagen on regeneration of sciatic nerve.
Turchaninova. L N LN; Kolosova. L I LI; Malinin. V V VV; Moiseeva. A B AB; Nozdrachev. A D AD; Khavinson. V K VK
Key Findings
- Intramuscular cortagen at 10 µg/kg for 10 days boosted nerve fiber growth rate by ~27% in rats.
- The same treatment increased nerve conduction velocity by ~40% during regeneration.
- The experiment was performed after surgical transection and suturing of the sciatic nerve, a severe injury model.
Practical Outcomes
- Cortagen shows promise for enhancing nerve repair in animal models, but there are no human studies, safety data, or dosing guidelines yet. Biohackers should treat this as preliminary evidence and not a ready-to-use protocol. Further research is needed before considering self‑administration for nerve health or recovery.
Summary
In a rat study, giving the tetrapeptide cortagen (10 µg per kg body weight) by muscle injection for 10 days after a sciatic nerve cut helped the nerve grow faster and conduct signals better—about 27% faster growth and 40% quicker signal speed.
Abstract
Intramuscular injection of 10 microg/kg cortagen to rats during 10 days after transsection and suturing of the sciatic nerve increased the growth rate and conduction velocity in the regenerating nerve fibers by 27% and 40%, respectively.
Study Information
Provider
pubmed
Year
2000