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AEDP, Ala-Glu-Asp-Pro, Cortex Tetrapeptide
A synthetic tetrapeptide bioregulator that targets the brain to promote neuroprotection, reduce inflammation, and enhance cognitive function.
Turchaninova. L N LN; Kolosova. L I LI; Malinin. V V VV; Moiseeva. A B AB; Nozdrachev. A D AD; Khavi...
In a rat study, giving the tetrapeptide cortagen (10 µg per kg body weight) by muscle injection for 10 days after a sciatic nerve cut helped the nerve grow faster and conduct signals better—about 27% faster growth and 40% quicker signal speed.
Kozina. L S LS
A study in rats found that giving the peptide cortagen (along with another peptide, epithalon) lowered markers of oxidative damage in the brain and blood, but it also reduced the natural antioxidant activity in those tissues. The work was done in animals using injections, so it doesn't directly tell us how to use cortagen in people.
Kazakova. T B TB; Barabanova. S V SV; Novikova. N S NS; Glushikhina. M S MS; Khavinson. V Kh VKh; Ma...
A study in rats found that the peptide Cortagen (along with Vilon and Epithalon) can change how much IL-2 messenger RNA is made in certain brain areas, and that the effect varies with how and when the peptide is given. This is an early, mechanistic finding and does not give clear guidance for human use.
Gumen. A V AV; Kozinets. I A IA; Shanin. S N SN; Malinin. V V VV; Rybakina. E G EG
In mice, older animals' immune cells make less of a signal that helps T‑cells work, and three short synthetic peptides (Vilon, Epithalon, Cortagen) change this signal differently in young versus old mice. This hints that such peptides might tweak age‑related immune decline, but the work is early and done only in mouse cells.
Khavinson. V Kh VKh; Lezhava. T A TA; Malinin. V V VV
The study tested several synthetic short peptides, including Cortagen, on blood cells taken from people aged 75‑88. It found that these peptides turned on ribosome genes and loosened tightly packed DNA regions, which are changes usually linked to aging. The work was done on isolated cells, not on living volunteers, and no health or performance outcomes were measured.
Khavinson. V K VK
The study showed that a synthetic peptide called Cortagen (along with a few others) can make rat brain tissue pieces grow faster when they are kept alive in a dish. Each peptide only helped the type of tissue it was originally derived from, suggesting a kind of tissue‑specific boost.
Khavinson. V Kh VKh; Rybakina. E G EG; Malinin. V V VV; Pivanovich. I Yu IY; Shanin. S N SN; Korneva...
In mouse thymus cells, the short peptide Cortagen (Ala-Glu-Asp-Pro) did not boost cell growth or activate a key immune signaling pathway, unlike two other peptides tested.
Zarubina. I V IV; Shabanov. P D PD
In rats with long‑term brain blood‑flow problems, two peptides—cortexin (a natural polypeptide) and cortagen (a synthetic version)—helped the animals recover normal behavior faster and protected brain tissue from oxidative damage.
Zarubina. I V IV; Shabanov. P D PD
In rats, a brain‑specific protein mix called cortagen helped protect the brain from damage caused by repeated low‑oxygen events. It lowered the severity of neurological problems, improved the animals' normal behavior, and acted as an antioxidant during both early and later stages of the damage process.
Lezhava. T T; Jokhadze. T T; Monaselidze. J J; Buadze. T T; Gaiozishvili. M M; Sigua. T T; Khujadze....
The study looked at how short peptide mixes, including Cortagen, change the way DNA is packed in white blood cells from people aged 75‑88. Normally, aging makes DNA tighter (heterochromatin), which can turn off important genes. The peptides partially loosen this packing in specific chromosome regions, boosting activity of ribosomal genes, but they don’t affect all types of tightly packed DNA.
Anisimov. Sergey V SV; Khavinson. Vladimir Kh VKh; Anisimov. Vladimir N VN
A short study in middle‑aged mice showed that five daily injections of the synthetic peptide Cortagen changed the activity of about 110 genes in the heart, with some genes turning on up to five times more and others turning off about three times. The changes overlapped partly with those seen for other anti‑aging peptides and melatonin, hinting at possible heart‑related effects, but the work stopped at gene activity and did not test actual health outcomes.
Kazakova. T B TB; Barabanova. S V SV; Khavinson. V Kh VKh; Glushikhina. M S MS; Parkhomenko. E P EP;...
In a lab test using mouse immune cells, three short synthetic peptides (Vilon, Epithalon, and Cortagen) were able to turn on a gene that makes the immune‑boosting protein interleukin‑2. Vilon and Epithalon were the strongest, while Cortagen had only a modest effect. The response changed with how much peptide was used and how long the cells were exposed.
Kuznik. B I BI; Pateiuk. A V AV; Baranchugova. L M LM; Rusaeva. N S NS
In chickens that had their pituitary gland removed early in life, blood, immune and clotting problems develop. Giving the peptide epithalon (Ala‑Glu‑Asp‑Gly) for 40 days fixed those issues, but the similar peptide cortagen (Ala‑Glu‑Asp‑Pro) did nothing.
Khavinson. V Kh VKh; Malinin. V V VV; Chalisova. N I NI; Grigor'ev. E I EI
The researchers tested Cortagen and several other brain‑, liver‑, and thymus‑derived peptides on rat tissue slices in a dish. They found that each peptide tended to affect only the type of tissue it came from, showing tissue‑specific actions, but the work was purely in vitro and done on rats of different ages.