Follistatin 315
Activin-Binding Protein, FSH-Suppressing Protein, FST-315, FS-315
BMD Alterations and Bone and Muscle Parameters During Menstrual Cessation With GnRH
Brief Summary
The investigators aim to investigate the effect of menstrual cessation in women with endometriosis treated with GnRH analogs for 6 months on bone mineral density and bone and muscle metabolism parameters and subsequently the effects of menstrual restoration after GnRH analogs discontinuation on the above measured parameters
Detailed Description
Prospective, open-label, controlled 12month observational study Premenopausal women with surgically verified endometriosis will receive goserelin 1 injection per month for 6 months. Subsequently goserelin will be discontinued and patients will be monitored for another 6 months after menstrual restoration. Age- and BMI-matched premenopausal, health women will serve as controls. Controls will receive no treatment.
Interventions
Primary Outcomes
Trial Information
NCT04203212
Completed
OBSERVATIONAL
424 General Military Hospital
December 15, 2025