Measure:
Change From Baseline in Muscle Tissue PGC1alpha (AU) at 8 Weeks
TimeFrame:
Baseline and 8 Weeks
Description:
Western blot measurement of the transcriptional coactivator gene PGC1alpha involved in mitochondrial biogenesis will be assessed using relative band intensities of the pre-treatment (Baseline) and post-treatment (8 Weeks) specimens with digitally quantified using ImageJ software.
Measure:
Mean Change From Baseline in Muscle Tissue AMPK at 8 Weeks
TimeFrame:
8 weeks
Description:
Western blot measurement of AMPK will be assessed using relative band intensities of the pre-treatment and post-treatment specimens with digitally quantified using ImageJ software).
Measure:
Mean Change From Baseline in Muscle Tissue LKB1 at 8 Weeks
TimeFrame:
8 weeks
Description:
Western blot measurement of LKB1 will be assessed using relative band intensities of the pre-treatment and post-treatment specimens with digitally quantified using ImageJ software) .
Measure:
Mean Change From Baseline in Cristae-associated Mitofillin Levels at 8 Weeks
TimeFrame:
8 weeks
Description:
Western blot measurement of Mitofillin will be assessed using relative band intensities of the pre-treatment and post-treatment specimens with digitally quantified using ImageJ software.
Measure:
Mean Change From Baseline in Muscle Tissue Follistatin at 8 Weeks
TimeFrame:
8 weeks
Description:
Regulators of muscle growth and regeneration including follistatin will be assessed by Western using relative band intensities of the pre-treatment and post-treatment specimens with digitally quantified using ImageJ software).
Measure:
Mean Change From Baseline in Muscle Tissue Myostatin at 8 Weeks
TimeFrame:
8 weeks
Description:
Regulators of muscle growth and regeneration including myostatin will be assessed by Western using relative band intensities of the pre-treatment and post-treatment specimens with digitally quantified using ImageJ software).
Measure:
Mean Change From Baseline in Muscle Tissue Myogenin at 8 Weeks
TimeFrame:
8 weeks
Description:
Modulators of skeletal muscle regeneration by Western will include myogenin will be assessed using relative band intensities of the pre-treatment and post-treatment specimens with digitally quantified using ImageJ software).
Measure:
Mean Change From Baseline in Muscle Tissue Myf5 at 8 Weeks
TimeFrame:
8 weeks
Description:
Modulators of skeletal muscle regeneration My5 will be assessed by Western using relative band intensities of the pre-treatment and post-treatment specimens with digitally quantified using ImageJ software).
Measure:
Mean Change From Baseline in Muscle Tissue MyoD at 8 Weeks
TimeFrame:
8 weeks
Description:
Modulators of skeletal muscle regeneration MyoD will be assessed by Western using relative band intensities of the pre-treatment and post-treatment specimens with digitally quantified using ImageJ software).
Measure:
Mean Change From Baseline in Muscle Tissue MEF2a at 8 Weeks
TimeFrame:
8 weeks
Description:
Modulators of skeletal muscle regeneration MEF2a will be assessed by Western using relative band intensities of the pre-treatment and post-treatment specimens with digitally quantified using ImageJ software).
Measure:
Mean Change From Baseline in Muscle Tissue Dysferlin at 8 Weeks
TimeFrame:
8 weeks
Description:
Structure associated indicators including dysferlin will be assessed by Western using relative band intensities of the pre-treatment and post-treatment specimens with digitally quantified using ImageJ software).
Measure:
Mean Change From Baseline in Muscle Tissue Utrophin at 8 Weeks
TimeFrame:
8 weeks
Description:
Structure associated indicators including utrophin will be assessed by Western using relative band intensities of the pre-treatment and post-treatment specimens with digitally quantified using ImageJ software).