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Follistatin 344

FS-344, Activin-Binding Protein, FST344

Quick Stats
Studies 2
Trials 73
Completed NA INTERVENTIONAL NCT04028128

High Flavonols Cocoa Intake for the Improvement of Body Fat Composition in Athletes

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

The decrease in body fat percentage improves exercise performance, reducing race time. The intake of cocoa improves the body fat composition in obese and diabetic people by improving their cardiovascular disease risk factors. Although epidemiological studies indicate that healthy subjects who consume cocoa have lower body fat composition, there is no study indicating whether cocoa improves fat composition in athletes. The aim of the study was to determine if the intake of cocoa rich in flavonoids improves the fat composition of athletes, modifying the systemic levels of adipokines (folistatin, myostatin and leptin), resulting in an improvement of physical performance.

Detailed Description

The objective of this project was to investigate the effects of chronic daily consumption of high in flavanols cocoa in body composition and performance of endurance athletes: A randomized, blinded, parallel placebo controlled intervention study was carried out in endurance athletes . The number of male athletes enrolled in the study was 40, with ages between 18 and 50 years and an aerobic power consumption of oxygen greater than or equal to 55 mL / kg / min). The intervention was carried out for 10 weeks. Cocoa or placebo (maltodextrin) were supplied in sachets of a single daily dose. Cocoa provided 425 mg of flavanols/ day. Athlete's body composition was evaluated by dual-energy X-ray absorptiometry (DEXA). Exercise performance was evaluated with a treadmill test protocol determining the maximum aerobic capacity and also by determining the time necessary to run a kilometer at maximum speed. Adipokines (follistatin, myostatin and leptin) in plasma and serum samples were determined by ELISA. Diet was determined by three 24h-recall questionnaries and a Food Frecuency questionnaire.

Interventions

Name: Cocoa group
Type: DIETARY_SUPPLEMENT
Description: Athletes performed a training program and consumed 5 g of cocoa (425 mg of flavonoids) mixed with semi-skimmed fat milk, daily for 10 weeks.
Name: Placebo group
Type: DIETARY_SUPPLEMENT
Description: The athletes performed the same training program of the cocoa group and they took for 10 weeks 5 g of maltodextrin mixed with semi-skimmed fat milk.

Primary Outcomes

Measure: Change of body fat mass at 10 weeks
TimeFrame: Fat mass was analyzed at the beginning (baseline time = 0) and after 10 weeks of intervention
Description: Energy X-ray absorptiometry (DEXA).

Trial Information

NCT ID

NCT04028128

Status

Completed

Study Type

INTERVENTIONAL

Phases

NA

Sponsor

Universidad Europea de Madrid

Last Updated

December 15, 2025

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