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Follistatin 344

FS-344, Activin-Binding Protein, FST344

Quick Stats
Studies 2
Trials 73
Not Yet Recruiting NA INTERVENTIONAL NCT07005193

Effects of LPG and Ventilation Interventions on Reducing HAP and Improving Cardiopulmonary Health

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

The goal of this clinical trial is to evaluate the independent and synergistic effects of liquefied petroleum gas (LPG) substitution and improved ventilation on household air pollution (HAP) reduction and cardiopulmonary health. The main questions it aims to answer are: 1. Does LPG substitution or improved ventilation reduce HAP and improve cardiopulmonary health? 2. Would the combined intervention of LPG substitution and improved ventilation outperform single interventions? 3. What is the cost-effectiveness of such interventions, and are they sustainable? Participants will be randomized in 4 groups: A: Solid fuel + no ventilation facilities group (150 households): Continued use of solid fuels without ventilation facilities, with a one-time financial compensation provided post-intervention; B: Liquefied petroleum gas (LPG) + no ventilation facilities group (150 households): Provided with LPG stoves and instructed to use them for cooking, with regular LPG supply during the intervention period; C: Solid fuel + ventilation facilities group (150 households): Maintained solid fuel usage habits while provided with ventilation facilities and instructed to use them during cooking, with electricity costs compensated during the intervention; D: LPG + ventilation facilities group (150 households): Provided with both LPG stoves and ventilation facilities, instructed to use both during cooking, with regular LPG supply and electricity cost compensation throughout the intervention period.

Interventions

Name: Using rang hood during cooking
Type: DEVICE
Description: Cooking ventilation facilities
Name: Using liquefied gas for cooking
Type: BEHAVIORAL
Description: Using liquefied gas instead of solid fuels for cooking

Primary Outcomes

Measure: Change in the Number of Ultrafine particles (UFP)
TimeFrame: 1 year, with follow-ups at 6, 12, 24, and 36 months
Description: Unit: particles/cm³, Measuring instrument: TSI NanoScan (TSI, USA), MicroPEM (PennEngineering, USA), Gillian5000 (Sensidyne, USA), Measurement method: Monitoring device sensors.
Measure: Change in the Concentrations of PM2.5
TimeFrame: 1 year, with follow-ups at 6, 12, 24, and 36 months
Description: Unit: ug/m3, Measuring instrument: TSI NanoScan (TSI, USA), MicroPEM (PennEngineering, USA), Gillian5000 (Sensidyne, USA), Bbair (Yuanrui Environmental Protection Technology Co., Ltd, China) , Measurement method: Monitoring device sensors.
Measure: Change in the Heart Rate Variability (HRV) Measured by 12-lead ECG
TimeFrame: 1 year, with follow-ups at 6, 12, 24, and 36 months
Description: Heart rate variability measured using standard 12-lead electrocardiogram (ECG). Measuring instrument: HeaLink heart rate sensor (Henan Link Medical Technology Co., Ltd., China), The time-domain indicators include:SDNN: Standard deviation of all normal-to-normal (NN) intervals over 24 hours / SDANN: Standard deviation of the average NN intervals calculated over 5-minute segments throughout 24 hours / RMSSD: Root mean square of successive differences between adjacent NN intervals over 24 hours. The frequency-domain indicators include: TP: Total power / LF: Low-frequency power / HF: High-frequency power / LF/HF: Ratio of low-frequency to high-frequency power.
Measure: Change in the Forced Vital Capacity (FVC)
TimeFrame: 1 year, with follow-ups at 6, 12, 24, and 36 months
Description: Forced Vital Capacity measured using spirometer (HI105; Chestgraph, Japan). Units of Measure: Liters. Method of Measurement: Standardized spirometric testing protocol.
Measure: Change in the Forced Expiratory Volume in 1 Second (FEV1)
TimeFrame: 1 year, with follow-ups at 6, 12, 24, and 36 months
Description: Forced Expiratory Volume in 1 Second measured using spirometer (HI105; Chestgraph, Japan). Units of Measure: Liters. Method of Measurement: Standardized spirometric testing protocol.

Trial Information

NCT ID

NCT07005193

Status

Not Yet Recruiting

Study Type

INTERVENTIONAL

Phases

NA

Sponsor

Huazhong University of Science and Technology

Last Updated

December 15, 2025

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