Literature-Based Discovery to Elucidate the Biological Links between Resistant Hypertension and COVID-19.
Kartchner. David D; McCoy. Kevin K; Dubey. Janhvi J; Zhang. Dongyu D; Zheng. Kevin K; Umrani. Rushda R; Kim. James J JJ; Mitchell. Cassie S CS
Key Findings
- COVID‑19 infection is associated with new or worsening resistant hypertension.
- Literature mining highlighted endocrine and inflammatory pathways as major themes linking the two conditions.
- GHRP‑2 (growth hormone‑releasing peptide‑2) appeared among the top molecules potentially connecting COVID‑19 to resistant hypertension.
Practical Outcomes
- For biohackers, the takeaway is that monitoring blood pressure after COVID‑19 infection is wise, especially if you’re using hormone‑modulating peptides like GHRP‑2. While the study doesn’t give dosing advice, it suggests that GHRP‑2 could influence blood‑pressure regulation, so consider tracking your BP if you include it in your regimen.
Summary
A big computer‑driven study scanned millions of papers and found that people who had COVID‑19 can develop stubborn high blood pressure. The analysis linked this to several hormone‑related pathways, and even flagged growth‑hormone‑releasing peptide‑2 (GHRP‑2) as one of many molecules that might be involved.
Abstract
Multiple studies have reported new or exacerbated persistent or resistant hypertension in patients previously infected with COVID-19. We used literature-based discovery to identify and prioritize multi-scalar explanatory biology that relates resistant hypertension to COVID-19. Cross-domain text mining of 33+ million PubMed articles within a comprehensive knowledge graph was performed using SemNet 2.0. Unsupervised rank aggregation determined which concepts were most relevant utilizing the normalized HeteSim score. A series of simulations identified concepts directly related to COVID-19 and resistant hypertension or connected via one of three renin-angiotensin-aldosterone system hub nodes (mineralocorticoid receptor, epithelial sodium channel, angiotensin I receptor). The top-ranking concepts relating COVID-19 to resistant hypertension included: cGMP-dependent protein kinase II, MAP3K1, haspin, ral guanine nucleotide exchange factor, N-(3-Oxododecanoyl)-L-homoserine lactone, aspartic endopeptidases, metabotropic glutamate receptors, choline-phosphate cytidylyltransferase, protein tyrosine phosphatase, tat genes, MAP3K10, uridine kinase, dicer enzyme, CMD1B, USP17L2, FLNA, exportin 5, somatotropin releasing hormone, beta-melanocyte stimulating hormone, pegylated leptin, beta-lipoprotein, corticotropin, growth hormone-releasing peptide 2, pro-opiomelanocortin, alpha-melanocyte stimulating hormone, prolactin, thyroid hormone, poly-beta-hydroxybutyrate depolymerase, CR 1392, BCR-ABL fusion gene, high density lipoprotein sphingomyelin, pregnancy-associated murine protein 1, recQ4 helicase, immunoglobulin heavy chain variable domain, aglycotransferrin, host cell factor C1, ATP6V0D1, imipramine demethylase, TRIM40, H3C2 gene, COL1A1+COL1A2 gene, QARS gene, VPS54, TPM2, MPST, EXOSC2, ribosomal protein S10, TAP-144, gonadotropins, human gonadotropin releasing hormone 1, beta-lipotropin, octreotide, salmon calcitonin, des-n-octanoyl ghrelin, liraglutide, gastrins. Concepts were mapped to six physiological themes: altered endocrine function, 23.1%; inflammation or cytokine storm, 21.3%; lipid metabolism and atherosclerosis, 17.6%; sympathetic input to blood pressure regulation, 16.7%; altered entry of COVID-19 virus, 14.8%; and unknown, 6.5%.
Study Information
pubmed
2023
2023-09-21T00:00:00.000Z
10.3390/biology12091269
4
163