GHRP-2, GHRH and SRIF interrelationships during chronic administration of GHRP-2 to humans.
Bowers. C Y CY; Granda-Ayala. R R
Key Findings
- Chronic (7‑30 day) GHRP‑2 or GHRH alone can turn an additive GH response into a synergistic one when combined.
- The pattern of synergy differs between GHRP‑2‑driven and GHRH‑driven protocols.
- GH response desensitization during chronic use is influenced by dosage and administration frequency.
Practical Outcomes
- For self‑experimenters, pairing GHRP‑2 with GHRH may boost growth‑hormone spikes more than using either alone, but keep doses modest and space administrations to avoid blunting the response. Start with low‑to‑moderate daily doses (e.g., 100‑200 µg GHRP‑2) and consider intermittent schedules (e.g., 5‑6 days on, 1‑2 days off) to maintain sensitivity.
Summary
Giving GHRP‑2 over several days changes how the body reacts to growth‑hormone‑releasing hormone (GHRH). Instead of just adding up their effects, they work together in a stronger, synergistic way, but the exact benefit depends on how much and how often you take it, because the response can fade if you over‑dose or use it too frequently.
Abstract
Studies with chronic GHRP-2 or GHRH administration were performed to demonstrate and better understand the interrelationships between GHRP-2, GHRH and SRIF. Normal younger and older men and women received chronic GHRP-2, GHRH or GHRP-2 + GHRH for 7-30 days. It was demonstrated that chronic administration of either GHRP-2 or GHRH could convert an additive GHRP-2 + GHRH GH response to a synergistic one. In addition, the type of synergistic response induced by chronic GHRP-2 versus GHRH was different. Whether the GH response becomes desensitized during chronic administration depends in part on the dosage and frequency of administration. The potential to learn more about the in vivo actions of GHRP relative to the regulation of GH secretion is underscored by studying the GH responses to GHRP-2, GHRH and GHRP-2 + GHRH.
Study Information
pubmed
1996