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LL-37

Cathelicidin, hCAP-18, FALL-39, CAP-18

Quick Stats
Studies 2230
Trials 95
Withdrawn NA INTERVENTIONAL NCT01026363

hCAP18 Levels and Vitamin D Deficiency in Chronic Kidney Disease

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

The human immune system produces a protein called hCAP18 (also known as LL-37 or cathelicidin). This protein is believed to help the body to fight infections. Studies suggest that vitamin D may important in the production of hCAP18. This study is designed to test the ability of two different forms of vitamin D to affect levels of hCAP18. Vitamin D and hCAP18 levels will be measured during an initial visit. Individuals who are vitamin D deficient will be randomly assigned to receive one of two forms of vitamin D for two weeks. After this, follow-up levels will be measured.

Interventions

Name: Ergocalciferol
Type: DRUG
Description: Ergocalciferol 50,000 IU capsule, one dose every other day x 5 doses
Name: Calcitriol
Type: DRUG
Description: 0.25 mcg tablet once daily for 14 days

Primary Outcomes

Measure: hCAP18 levels
TimeFrame: 2 weeks
Description:

Trial Information

NCT ID

NCT01026363

Status

Withdrawn

Study Type

INTERVENTIONAL

Phases

NA

Sponsor

Massachusetts General Hospital

Last Updated

December 15, 2025