Menu
Peptide Database
Results
No peptides found
Featured

Use search to browse all 100+ peptides

LL-37

Cathelicidin, hCAP-18, FALL-39, CAP-18

Quick Stats
Studies 2230
Trials 95
Completed EARLY PHASE1 INTERVENTIONAL NCT06597708

Dietary Diversities: Exploring the Influence of Keto Diet and Intermittent Fasting on Oral Health and Salivary Inflammatory Biomarkers

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

This study aims to investigate the impact of short term, two distinct dietary interventions, namely the Keto diet and Intermittent Fasting on oral health by measuring the severity of: * Periodontal diseases (Gingivitis). * Oral health status (Plaque index). As well as measuring the impact of these different dietary pattern on the levels of C- Reactive Protein, IL-6, TNF-a in mean of inflammatory biomarkers as well as LL- 37 peptide as well as measuring salivary flow and ph. Objectives of the study 1. Evaluate the impact of Keto diet and Intermittent Fasting on oral health among the Iraqi population. 2. Assess changes in inflammatory biomarkers within the study groups before and after the intervention period. 3. Compare the effects of Keto diet and Intermittent Fasting on oral health and inflammatory biomarkers between the two intervention groups. 4. Examine the variations in oral health and inflammatory biomarkers within each group by comparing the baseline (Iraqi diet) and post-intervention stages. 5. Investigate the influence of Keto diet and Intermittent Fasting on the levels of LL37, an antimicrobial peptide.

Interventions

Name: keto diet
Type: BEHAVIORAL
Description: They were advised to eat ad libitum but to limit their carbohydrate intake to a maximum of 20-40 g/day to derive at leasut 75%, 15-20%, and 5-10% of total energy from fats, protein, and carbohydrates, respectively.
Name: intermittent fasting with calorie restriction
Type: BEHAVIORAL
Description: The 16/8 TRF group was asked to consume their daily calorie intake during an 8-hour window during the daytime and then fast for the remaining 16 hours each day throughout the intervention period.

Primary Outcomes

Measure: effect of keto diet on oral health
TimeFrame: 30 days
Description: effect of keto diet on oral health by measuring the plaque index and bleeding on probing index
Measure: effect of intermittent fasting on oral health
TimeFrame: 30 days
Description: effect of intermittent fasting on oral health by measuring the plaque index and bleeding on probing index

Trial Information

NCT ID

NCT06597708

Status

Completed

Study Type

INTERVENTIONAL

Phases

EARLY PHASE1

Sponsor

Al-Mustansiriyah University

Last Updated

December 15, 2025