Completed
NA
INTERVENTIONAL
NCT05779410
Vitamin D in Healthy Adults After Strenuous Endurance Exercise
View on ClinicalTrials.gov
Updated Dec 15, 2025
Brief Summary
The purpose of this study was to investigate the effects of vitamin D supplementation on biochemical response and aerobic capacity after strenuous endurance exercise (SEE).
Detailed Description
All participants conducted a graded exercise test on an ergometric bicycle to determine the maximal oxygen consumption (VO2max) before and after supplementation, and the speed equivalent to 65% VO2max was conducted for a SEE test by ergometric bicycle for 2 hours, followed by increasing 100 RPM until exhaustion. Venous blood samples were drawn before, immediately after, 2-hour after, 4-hour after, 8-hour after, and 24-hour after the SEE test to determine the concentrations of biomarkers. Data was analyzed by Two-way mixed design ANOVA.
Interventions
Name:
Vitamin D
Type:
DIETARY_SUPPLEMENT
Description:
Participants received 5,000 IU of vitamin D orally twice daily for 4 weeks
Name:
Medium-chain triglycerides
Type:
DIETARY_SUPPLEMENT
Description:
Participants received the same amount of placebo matching vitamin D orally twice daily for 4 weeks
Primary Outcomes
Measure:
Concentration of Neutrophil
TimeFrame:
before exercise
Description:
Measure:
Concentration ofNeutrophil
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of Neutrophil
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of Neutrophil
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of Neutrophil
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of Neutrophil
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of eosinophil
TimeFrame:
before exercise
Description:
Measure:
Concentration of eosinophil
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of eosinophil
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of eosinophil
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of eosinophil
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of eosinophil
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of basophil
TimeFrame:
before exercise
Description:
Measure:
Concentration of basophil
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of basophil
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of basophil
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of basophil
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of basophil
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of monocyte
TimeFrame:
before exercise
Description:
Measure:
Concentration of monocyte
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of monocyte
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of monocyte
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of monocyte
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of monocyte
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of lymphocyte
TimeFrame:
before exercise
Description:
Measure:
Concentration of lymphocyte
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of lymphocyte
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of lymphocyte
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of lymphocyte
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of lymphocyte
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of CD4+
TimeFrame:
before exercise
Description:
Measure:
Concentration of CD4+
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of CD4+
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of CD4+
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of CD4+
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of CD4+
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of CD8+
TimeFrame:
before exercise
Description:
Measure:
Concentration of CD8+
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of CD8+
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of CD8+
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of CD8+
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of CD8+
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of CD19+
TimeFrame:
before exercise
Description:
Measure:
Concentration of CD19+
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of CD19+
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of CD19+
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of CD19+
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of CD19+
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of CD56+
TimeFrame:
before exercise
Description:
Measure:
Concentration of CD56+
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of CD56+
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of CD56+
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of CD56+
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of CD56+
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of IgA
TimeFrame:
before exercise
Description:
Measure:
Concentration of IgA
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of IgA
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of IgA
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of IgA
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of IgA
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of Cathelicidin
TimeFrame:
before exercise
Description:
Measure:
Concentration of Cathelicidin
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of Cathelicidin
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of Cathelicidin
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of Cathelicidin
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of Cathelicidin
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of TNF-α
TimeFrame:
before exercise
Description:
Measure:
Concentration of TNF-α
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of TNF-α
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of TNF-α
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of TNF-α
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of TNF-α
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of IL-1β
TimeFrame:
before exercise
Description:
Measure:
Concentration of IL-1β
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of IL-1β
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of IL-1β
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of IL-1β
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of IL-1β
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of IFN-γ
TimeFrame:
before exercise
Description:
Measure:
Concentration of IFN-γ
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of IFN-γ
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of IFN-γ
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of IFN-γ
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of IFN-γ
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of IL-2
TimeFrame:
before exercise
Description:
Measure:
Concentration of IL-2
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of IL-2
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of IL-2
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of IL-2
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of IL-2
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of IL-4
TimeFrame:
before exercise
Description:
Measure:
Concentration of IL-4
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of IL-4
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of IL-4
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of IL-4
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of IL-4
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of IL-8
TimeFrame:
before exercise
Description:
Measure:
Concentration of IL-8
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of IL-8
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of IL-8
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of IL-8
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of IL-8
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of IL-10
TimeFrame:
before exercise
Description:
Measure:
Concentration of IL-10
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of IL-10
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of IL-10
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of IL-10
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of IL-10
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of TBARS
TimeFrame:
before exercise
Description:
Measure:
Concentration of TBARS
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of TBARS
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of TBARS
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of TBARS
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of TBARS
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of PC
TimeFrame:
before exercise
Description:
Measure:
Concentration of PC
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of PC
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of PC
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of PC
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of PC
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of SOD
TimeFrame:
before exercise
Description:
Measure:
Concentration of SOD
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of SOD
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of SOD
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of SOD
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of SOD
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of catalase
TimeFrame:
before exercise
Description:
Measure:
Concentration of catalase
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of catalase
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of catalase
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of catalase
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of catalase
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of GPx
TimeFrame:
before exercise
Description:
Measure:
Concentration of GPx
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of GPx
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of GPx
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of GPx
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of GPx
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of CK
TimeFrame:
before exercise
Description:
Measure:
Concentration of CK
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of CK
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of CK
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of CK
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of CK
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of LDH
TimeFrame:
before exercise
Description:
Measure:
Concentration of LDH
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of LDH
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of LDH
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of LDH
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of LDH
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of IL-6
TimeFrame:
before exercise
Description:
Measure:
Concentration of IL-6
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of IL-6
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of IL-6
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of IL-6
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of IL-6
TimeFrame:
24-hour after exercise
Description:
Measure:
Concentration of CRP
TimeFrame:
before exercise
Description:
Measure:
Concentration of CRP
TimeFrame:
immediately after exercise
Description:
Measure:
Concentration of CRP
TimeFrame:
2-hour after exercise
Description:
Measure:
Concentration of CRP
TimeFrame:
4-hour after exercise
Description:
Measure:
Concentration of CRP
TimeFrame:
8-hour after exercise
Description:
Measure:
Concentration of CRP
TimeFrame:
24-hour after exercise
Description:
Trial Information
NCT ID
NCT05779410
Status
Completed
Study Type
INTERVENTIONAL
Phases
NA
Sponsor
Taipei Medical University
Last Updated
December 15, 2025