Completed
PHASE4
INTERVENTIONAL
NCT05244018
Outcome of High Dose Vitamin D on Prognosis of Sepsis Requiring Mechanical Ventilation
View on ClinicalTrials.gov
Updated Dec 15, 2025
Brief Summary
There is a high prevalence of vitamin D deficiency in the critically ill patient population, with approximately 60% of patients found to be vitamin D deficient, (25(OH)D concentrations \<20 ng/mL) and an additional 30% of patients being vitamin D insufficient, (25(OH)D = 20-30 ng/mL).Approximately 80% of sepsis/septic shock patients experience respiratory failure and require mechanical ventilation. Furthermore, several studies document that vitamin D deficiency could be associated with poor outcomes in critically ill patient.
Interventions
Name:
Vitamin D3 tablets
Type:
DRUG
Description:
Vitamin D3 tablets 50,000 IU units
Name:
Vitamin D tablets
Type:
DRUG
Description:
Vitamin D tablets 5000 units as daily requirements
Primary Outcomes
Measure:
Change in procalcitonin level (ng/ml) and antimicrobial peptide cathelicidin (LL37) (ng/ml) level at day 7.
TimeFrame:
7 days
Description:
Change in procalcitonin level (ng/ml) and antimicrobial peptide cathelicidin (LL37) (ng/ml) level at day 7.
Trial Information
NCT ID
NCT05244018
Status
Completed
Study Type
INTERVENTIONAL
Phases
PHASE4
Sponsor
Ain Shams University
Last Updated
December 15, 2025