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LL-37

Cathelicidin, hCAP-18, FALL-39, CAP-18

Quick Stats
Studies 2230
Trials 95
Completed OBSERVATIONAL NCT04292548

Salivary TAS, TOS, LL-37 and Dental Status in Passive Smoking Children

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

The aim of the present study was to determine the effect of passive smoking on the levels of salivary TAS, TOS, LL-37 and dental status in children.In the study the parents of children were asked to fill out a complete survey about smoking habits. After filling out the questionnaire, according to the survey results, a total of 180 children were included to the study as follows; 90 children exposed to passive smoking, and 90 children in the control group (unexposed controls). Also demographic data were recorded (age, gender, parental education levels, child's tooth-brushing habit and child's daily dietary sugar exposure, family income). Dental examination of children were performed and caries prevalance of the patients were recorded. Unstimulated saliva samples were collected from children. Saliva 'cotinine levels' which are expected to increase in passive smoking group; 'antimicrobial peptide LL-37' and oxidative stress markers 'total antioxidant status' (TAS), and' total oxidant status' (TOS) were evaluated by using Enzyme-linked immunosorbent assay (ELISA). The obtained data parameters of the two groups were evaluated and comparison was performed.

Interventions

Name: taking saliva samples to determine TAS, TOS and LL-37
Type: DIAGNOSTIC_TEST
Description:

Primary Outcomes

Measure: salivary oxidative stress values: TAS level
TimeFrame: 1 day (once after the dental examination)
Description: Unstimulated saliva samples were collected from children.
Measure: salivary oxidative stress values: TOS level
TimeFrame: 1 day (once after the dental examination)
Description: Unstimulated saliva samples were collected from children.
Measure: salivary LL-37 level
TimeFrame: 1 day (once after the dental examination)
Description: Unstimulated saliva samples were collected from children.
Measure: salivary cotinine levels
TimeFrame: 1 day (once after the dental examination)
Description: Unstimulated saliva samples were collected from children for describing passive smoking children.

Trial Information

NCT ID

NCT04292548

Status

Completed

Study Type

OBSERVATIONAL

Sponsor

Merve Erkmen Almaz

Last Updated

December 15, 2025