The Application of a Novel Intense Pulsed Light in the Treatment of Rosacea-Like Mice.
Tian. Run R; Jia. Yongbin Y; Xie. Li L; Wen. Xiang X
Key Findings
- Dual‑band IPL (530‑650 nm + 900‑1200 nm) most effectively reduced skin redness and inflammatory cells in rosacea‑like mice.
- IPL treatment lowered blood vessel density (CD31) and mast cell numbers, indicating anti‑inflammatory effects.
- Skin barrier function improved (better stratum corneum and keratinocyte permeability) with the dual‑band filter.
Practical Outcomes
- For DIY skin‑care enthusiasts, this suggests that using an IPL device with combined visible (530‑650 nm) and near‑infrared (900‑1200 nm) wavelengths may be more effective for rosacea‑type redness than single‑band settings. While the data are from mice, the findings support experimenting with dual‑band IPL protocols, keeping sessions spaced 24 hours apart and using low fluence (~10 J/cm²). Safety and efficacy in humans still need confirmation.
Summary
In mice that develop rosacea‑like skin inflammation after being given the antimicrobial peptide LL‑37, a special intense pulsed light (IPL) treatment helped clear redness and inflammation. The best results came from using a dual‑band light filter (530‑650 nm and 900‑1200 nm), which cut down blood vessels, neutrophils, and mast cells, and improved the skin barrier.
Abstract
Rosacea is a chronic inflammatory disease that severely affects the quality of life of patients. Intense pulsed light (IPL) has been widely used in treating the erythema and telangiectasia in rosacea patients. However, the mechanism of its use is poorly understood. Our study objectives were to (i) assess the characteristic histological changes in animal models of rosacea with IPL over a microsecond pulse width, (ii) compare the effectiveness of different filter IPL irradiation. We utilized a mouse model of rosacea by injecting the antimicrobial peptide LL-37, with IPL operating over a dose of 10 J/cm<sup>2</sup> and several filter: 560-950 nm, 700-950 nm and dual wavelengths range (530-650 nm and 900-1200 nm). The single pulse was set to ten sub-pulses with a pulse width of 700 μs and delay time of 300 μs, respectively. Two treatment sessions were performed with a 24-h treatment interval. The erythema scoring criteria were used to evaluate the improvement in erythema before and after treatment. The number of blood vessels, inflammatory cells, and skin stratum corneum and keratinocyte permeability were also assessed. IPL significantly improved the erythema in rosacea-like mice. The use of a dual band filter at wavelength of 530-650 and 900-1200 nm significantly reduced the number of neutrophils in HE staining. Immunohistochemistry staining of CD31 confirmed the reduction of blood vessels. Also, the number of mast cells was reduced markedly with dual wavelength range and 700-950 nm. In addition, skin stratum corneum and keratinocyte permeability improved with 530-650 and 900-1200 nm. This novel IPL exhibited advantages in anti-inflammatory and repairing the permeability barrier of the rosacea-like mice skin. Photobiomodulation could potentially serve as the underlying mechanism of the novel IPL in the treatment of rosacea. It is a promising treatment option for rosacea.
Study Information
pubmed
2025
2025-05-30T00:00:00.000Z
10.1002/lsm.70034
55