Score
1
2025
pubmed
4 citations
Hydrogen-bonded organic framework for regulating pathogenic autoantigen and oxidative stress in psoriasis treatment.
Li. Yuhang Y; Yuan. Hui H; Cheng. Yi-Lun YL; Li. Qiu-Xia QX; Cao. Rong R; Li. Jin-Lin JL; Yin. Qi Q; Lu. Can-Zhong CZ; Liu. Tian-Fu TF
Key Findings
- The cobalt‑porphyrin framework (Co‑HOF) effectively scavenges reactive oxygen species.
- Co‑HOF directly binds to the pathogenic peptide LL‑37, reducing its activity.
- Applying Co‑HOF in a psoriasis mouse model markedly improved skin lesions and lowered inflammatory markers.
Practical Outcomes
- The main takeaway is that targeting oxidative stress and the LL‑37 peptide could be a promising strategy for psoriasis. However, there is no current consumer‑ready product or dosage guidance, so biohackers should treat this as early‑stage research and watch for future developments in topical or systemic LL‑37 inhibitors.
Summary
Scientists created a new cobalt‑based material that can mop up harmful reactive oxygen species and latch onto the peptide LL‑37, which drives psoriasis. In animal tests this material lowered skin inflammation, but it isn’t something you can buy or use right now.
Abstract
This study develops a cobalt porphyrin-based hydrogen-bonded organic framework (Co-HOF) to scavenge reactive oxygen species (ROS) and target the pathogenic peptide LL-37, thereby disrupting psoriasis progression.
Study Information
Provider
pubmed
Year
2025
Date
2025-04-03T00:00:00.000Z
DOI
10.1093/nsr/nwaf132
Citations
4