Antimicrobial peptide LL-37 disrupts plasma membrane and calcium homeostasis in <i>Candida albicans</i> via the Rim101 pathway.
Chen. Sheng-Yuan S-Y; Chang. Che-Kang C-K; Lan. Chung-Yu C-Y
Key Findings
- LL‑37 disrupts the plasma membrane of Candida albicans
- LL‑37 interferes with calcium homeostasis in the fungus
- The antifungal effect involves the Rim101 signaling pathway and links to oxidative stress
Practical Outcomes
- At this stage the findings are mainly scientific and not ready for direct use by biohackers. It suggests LL‑37 could become a future antifungal tool, but no safe dosage or protocol for self‑administration is provided.
Summary
The study shows that the human antimicrobial peptide LL‑37 can damage the cell membrane of the fungus Candida albicans and mess up its calcium balance, doing this through a specific signaling route called the Rim101 pathway. While this reveals how LL‑37 fights fungal infections, it doesn’t give a clear way for everyday health enthusiasts to use the peptide for personal health goals like longevity or performance.
Abstract
<i>Candida albicans</i> is a major human fungal pathogen, and antimicrobial peptides are key components of innate immunity. Studying the interplay between <i>C. albicans</i> and human antimicrobial peptides would enhance a better understanding of pathogen-host interactions. Moreover, potential applications of antimicrobial peptides in antifungal therapy have aroused great interest. This work explores new mechanisms of LL-37 against <i>C. albicans</i> and reveals the complex connection among calcium homeostasis, oxidative stress, signaling, and possibly organelle interaction. Notably, these findings support the possible use of antimicrobial peptides to prevent and treat fungal infections.
Study Information
pubmed
2023
2023-10-27T00:00:00.000Z
10.1128/spectrum.02551-23
13
99