Antibacterial peptides-loaded bioactive materials for the treatment of bone infection.
Wang. Gan G; Cui. Yutao Y; Liu. He H; Tian. Yuhang Y; Li. Shaorong S; Fan. Yi Y; Sun. Shouye S; Wu. Dankai D; Peng. Chuangang C
Key Findings
- LL‑37 is a natural peptide that kills bacteria and is less likely to cause resistance than traditional antibiotics
- Researchers are developing materials that slowly release LL‑37 directly at bone infection sites
- Loading LL‑37 into bioactive scaffolds can improve bone healing while fighting infection
Practical Outcomes
- For most biohackers, this review doesn’t give a direct protocol you can use now. It shows that future bone‑infection treatments may rely on peptide‑loaded implants, but you’ll need to wait for clinical products before applying it to personal health.
Summary
This paper reviews how the natural antimicrobial peptide LL‑37 can be put into special bone‑repair materials to fight infections after fractures. It explains why LL‑37 is good at killing bacteria without quickly causing resistance, and describes ways scientists are loading it onto scaffolds or coatings to keep it stable at the injury site. The article is mostly a theoretical overview, not a new treatment you can try yourself.
Abstract
Bacterial bone infection in open fractures is an urgent problem to solve in orthopedics. Antimicrobial peptides (AMPs), as a part of innate immune defense, have good biocompatibility. Their antibacterial mechanism and therapeutic application against bacteria have been widely studied. Compared with traditional antibiotics, AMPs do not easily cause bacterial resistance and can be a reliable substitute for antibiotics in the future. Therefore, various physical and chemical strategies have been developed for the combined application of AMPs and bioactive materials to infected sites, which are conducive to maintaining the local stability of AMPs, reducing many complications, and facilitating bone infection resolution. This review explored the molecular structure, function, and direct and indirect antibacterial mechanisms of AMPs, introduced two important AMPs (LL-37 and β-defensins) in bone tissues, and reviewed advanced AMP loading strategies and different bioactive materials. Finally, the latest progress and future development of AMPs-loaded bioactive materials for the promotion of bone infection repair were discussed. This study provided a theoretical basis and application strategy for the treatment of bone infection with AMP-loaded bioactive materials.
Study Information
pubmed
2023
2023-03-11T00:00:00.000Z
10.1016/j.colsurfb.2023.113255
11
149