Score
1
2022
pubmed
Correction: Nanomolar LL-37 induces permeability of a biomimetic mitochondrial membrane.
Jiang. Xin X; Yang. Chenguang C; Qiu. Jie J; Ma. Dongfei D; Xu. Cheng C; Hu. Shuxin S; Han. Weijing W; Yuan. Bing B; Lu. Ying Y
Key Findings
- LL‑37 can increase permeability of a biomimetic mitochondrial membrane at nanomolar concentrations
- The effect was observed in a simplified lab model, not in living organisms
- The correction does not change the core finding but fixes a reporting error
Practical Outcomes
- For most biohackers, this information isn’t directly usable. It suggests LL‑37 can interact with mitochondrial membranes, but there’s no guidance on safe dosing, delivery, or benefits for health, so it remains a mechanistic curiosity rather than a protocol.
Summary
A recent correction to a study about the peptide LL‑37 shows that, at very low (nanomolar) levels, it can make a lab‑made membrane that mimics mitochondria more leaky, but the paper is mostly about a technical detail and doesn’t give any real‑world advice for using LL‑37.
Abstract
Correction for 'Nanomolar LL-37 induces permeability of a biomimetic mitochondrial membrane' by Xin Jiang <i>et al.</i>, <i>Nanoscale</i>, 2022, https://doi.org/10.1039/d2nr05409d.
Study Information
Provider
pubmed
Year
2022
Date
2022-12-15T00:00:00.000Z
DOI
10.1039/d2nr90234f