Anti-Pythium insidiosum activity of MSI-78, LL-37, and magainin-2 antimicrobial peptides.
Denardi. Laura Bedin LB; Weiblen. Carla C; Ianiski. Lara Baccarin LB; Stibbe. Paula Cristina PC; Pinto. Stefania Campos SC; Santurio. Janio M JM
Key Findings
- LL‑37, MSI‑78, and magainin‑2 all inhibited P. insidiosum growth in vitro
- Minimum inhibitory concentrations ranged from 20 to 80 mg/L for all tested strains
- The authors suggest these peptides could be explored as future treatments for Pythium infections
Practical Outcomes
- At this stage the results are purely laboratory‑based and not ready for any DIY or clinical use. It signals a possible new direction for anti‑infection research, but biohackers don’t have actionable dosing or safety info to apply now.
Summary
The study shows that the natural peptide LL‑37, along with two other antimicrobial peptides, can kill the fungus‑like organism Pythium insidiosum in lab tests, but it doesn’t give any guidance on how to use it in people or animals.
Abstract
We investigated the anti-Pythium insidiosum activity of the antimicrobial peptides (AMPs) MSI-78, LL-37, and magainin-2. To detect the minimum inhibitory concentration (MIC), fourteen clinical strains were incubated with the AMPs following the CLSI M38-A2 protocol. All three AMPs showed antimicrobial activity with an MIC range of 20-80 mg/L against all strains. We concluded that the evaluated AMPs have great potential as anti-Pythium insidiosum agents, and their activity deserves to be more explored in further research. Antimicrobial peptides were tested against Pythium insidiosum, a microorganism that causes a difficult-to-treat disease in animals and humans. These peptides have been shown to be able to kill P. insidiosum and may be candidates for use in the treatment of this infection.
Study Information
pubmed
2022
2022-01-11T00:00:00.000Z
10.1007/s42770-022-00678-5
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