[Dynamics of immune and biochemical features of oral fluid in persons with caries receiving vitamin D].
Putneva. A S AS; Karavaeva. T M TM; Maximenya. M V MV; Fefelova. E V EV; Borodulina. I I II; Tereshkov. P P PP; Slobodenjuk. T F TF
Key Findings
- Low serum 25(OH)D3 (<30 ng/ml) is linked to reduced LL-37, secretory IgA, LBP, and total antioxidant activity in oral fluid, and higher lipid peroxidation products.
- Supplementing with native cholecalciferol (AquaDtrim) normalized LL-37, secretory IgA, LBP, and restored the lipid‑peroxidation/antioxidant balance in saliva.
- Higher caries severity (DMFT >9) correlates with lower vitamin D levels, indicating vitamin D status as a potential marker for oral health risk.
Practical Outcomes
- Measure your blood 25(OH)D3; if it's below ~30 ng/ml, consider a daily vitamin D3 supplement (e.g., 1000–2000 IU) to boost oral antimicrobial peptides like LL-37. Regular supplementation may improve saliva immunity and reduce oxidative stress, potentially slowing cavity formation. Monitor dental health and adjust dosage based on blood levels and personal response.
Summary
In young adults with cavities and low vitamin D, taking a regular dose of cholecalciferol (vitamin D3) raised the levels of the antimicrobial peptide LL-37 and other immune markers in saliva, while also improving antioxidant balance. This suggests that checking your vitamin D status and supplementing if low could help protect your teeth and gums.
Abstract
The aim of the study was to evaluate the content of the vitamin D metabolite (25(OH)D<sub>3</sub>) in the blood serum, the level of some indicators of the immune and peroxidic status in the oral fluid in people with carious processes of different intensities while taking the native solution of vitamin D (international non-proprietary name Cholecalciferol). The study included 47 people aged 20 to 22 with caries and low levels of 25(OH)D3 in blood serum. The control group consisted of 13 people with DMFT index of 0.00 [0.00; 0.00] and a normal serum content of 25(OH)D3. The amount of antimicrobial peptide cathelicidin LL-37, secretory immunoglobulin A, lipopolysaccharide binding protein (LBP) was determined in the oral fluid using ELISA reagent kits, and the content of intermediate lipid peroxidation products such as malondialdehyde (TBA-active products) and the level of total antioxidant activity were spectrophotometrically evaluated. Reduced serum concentrations of 25(OH)D3 were recorded predominantly in individuals with a DMFT index of more than 9.0. In patients with caries, at a concentration of 25(OH)D3 in blood serum below 30 ng/ml, a decrease in the values of secretory immunoglobulin A, lipopolysaccharide-binding protein, cathelicidin, and the level of total antioxidant activity was observed, accompanied by an increase in the number of intermediate products of lyoperoxidation in the oral fluid. The course intake of the native AquaDtrim vitamin D solution (Cholecalciferol) led to normalization of the values of certain immune and biochemical parameters (cathelicidin LL-37, secretory immunoglobulin A, LBP of the oral fluid) and restoration of balance in the system «lipid peroxidation - antioxidants». The results indicate the advisability of assessing the level of 25(OH)D<sub>3</sub> in the body for the diagnosis of pathological processes in the oral cavity and the use of vitamin D preparations in the prevention and complex therapy of carious process.
Study Information
pubmed
2020
10.17116/stomat20209906113
1
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