Cathelicidin LL-37 (an antimicrobial peptide)-induced colistin dependence in Acinetobacter baumannii.
Lee. Ji-Young JY; Hong. Yoon-Kyoung YK; Ko. Kwan Soo KS
Key Findings
- Exposure to LL‑37 can make A. baumannii develop dependence on colistin.
- The colistin‑dependent mutants become more sensitive to a range of other antibiotics.
- Genetic insertions (IS1595 or ATTT) in the LpxACD genes were identified in these mutants.
Practical Outcomes
- For most biohackers focused on longevity, metabolism, or performance, this study offers little direct guidance. It mainly informs microbiology and antibiotic resistance research, so it isn’t a useful protocol or supplement recommendation for personal health optimization.
Summary
Scientists found that when the human antimicrobial peptide LL‑37 is used on the bacteria Acinetobacter baumannii, the bacteria can become dependent on the antibiotic colistin. These colistin‑dependent bacteria become more vulnerable to many other antibiotics, and they show specific genetic changes.
Abstract
In this study, we demonstrated the development of colistin dependence in Acinetobacter baumannii isolates after exposure to the human cationic antimicrobial peptide LL-37. The LL-37-induced colistin-dependent mutants showed susceptibility to many other antibiotics and IS1595 or ATTT insertions in LpxACD.
Study Information
pubmed
2019
2019-12-30T00:00:00.000Z
10.1016/j.diagmicrobio.2019.114965
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