LL-37: Cathelicidin-related antimicrobial peptide with pleiotropic activity.
Fabisiak. Adam A; Murawska. Natalia N; Fichna. Jakub J
Key Findings
- LL-37 acts as a broad‑spectrum antimicrobial peptide.
- It has strong chemotactic and immunomodulatory effects.
- Potential therapeutic applications are discussed for immune, respiratory, gastrointestinal, and skin systems.
Practical Outcomes
- The review highlights LL-37’s promise as a drug candidate, but it doesn’t provide dosing guidelines or ready‑to‑use protocols. For biohackers, the main takeaway is that LL-37 is still in early research stages and not yet suitable for safe self‑experimentation.
Summary
LL-37 is a natural human peptide that kills germs and also helps steer the immune system. Scientists think it could be useful for treating skin problems, lung issues, gut disorders, and immune‑related diseases, but the paper is just a review and doesn’t give specific ways to use it.
Abstract
Antimicrobial peptides (AMPs) is a large family of compounds serving as natural antibiotics, widely distributed across the organism, mainly in mucus layers. They are designed to prevent pathogens from colonization. Among them, defensins and cathelicidins could be found. LL-37, the sole human cathelicidin draws particular attention because of its outstanding abilities. In addition to being a broad spectrum antibiotic, LL-37 has potent chemotactic and immunomodulatory properties. In this review, we discussed the potency of LL-37 as a therapeutic agent in four systems: immunological, respiratory, gastrointestinal and in the skin. We analyzed the main molecular pathways dependent on human cathelicidin and related them to specific diseases. We conclude that LL-37 shows a great potential to be further investigated and developed as a drug with clinical use.
Study Information
pubmed
2016
2016-04-07T00:00:00.000Z
10.1016/j.pharep.2016.03.015
118
90