Cathelicidins: peptides with antimicrobial, immunomodulatory, anti-inflammatory, angiogenic, anticancer and procancer activities.
Wong. Jack Ho JH; Ye. Xiu Juan XJ; Ng. Tzi Bun TB
Key Findings
- LL-37 has strong antimicrobial properties
- It modulates immune and inflammatory responses
- It can both suppress and promote cancer cell activity, and affects angiogenesis
Practical Outcomes
- For biohackers, LL-37 is interesting but not ready for self‑experimentation. There’s no clear dosage, safety profile, or delivery method, and its mixed cancer effects mean caution is needed. Focus on established, well‑studied interventions for health optimization while monitoring future research on LL-37.
Summary
LL-37 is a natural protein your body makes that can kill microbes, tweak the immune system, reduce inflammation, affect blood vessel growth, and even influence cancer cells, both positively and negatively. The paper is a broad review, so it doesn’t give specific dosing or protocols for DIY use.
Abstract
The family of peptides designated as cathelicidins was identified over a decade ago. Cathelicidins have since gained increasing recognition, both as endogenous antibiotics and as effector molecules of the innate immune system. The human cathelicidin LL-37 is widely expressed in human tissues and plays diverse biological roles. It contributes substantially to host defense and impacts multiple aspects of immunity. In view of the escalating importance of cathelicidins, the activities of LL-37 with an emphasis on antimicrobial, immunomodulatory, anti-inflammatory, angiogenic, anticancer and procancer effects are discussed in this review article.
Study Information
pubmed
2013
2013-08-31T00:00:00.000Z
10.2174/13892037113149990067
55