Treatment of high-level gentamicin-resistant Enterococcus faecalis endocarditis with daptomycin plus ceftaroline.
Sakoulas. George G; Nonejuie. Poochit P; Nizet. Victor V; Pogliano. Joseph J; Crum-Cianflone. Nancy N; Haddad. Fadi F
Key Findings
- Daptomycin plus ceftaroline cleared a resistant Enterococcus faecalis endocarditis case
- The drug combo showed strong synergy in lab experiments
- Ceftaroline increased daptomycin binding and made bacteria more sensitive to the innate peptide LL‑37
Practical Outcomes
- The main takeaway is that this antibiotic pairing could be a rescue option for serious, drug‑resistant heart infections, but it’s not a general health hack. It doesn’t provide a protocol you can use for longevity or performance, and it requires medical supervision.
Summary
A tough heart infection caused by a resistant bacteria was cured using two antibiotics together, daptomycin and ceftaroline. In lab tests they helped each other work better, and the combo also made the bacteria more vulnerable to the body’s natural defense peptide LL‑37. This shows a possible backup treatment for hard‑to‑treat infections, but it isn’t something most people can apply to everyday health routines.
Abstract
A recurrent case of left-sided endocarditis caused by high-level aminoglycoside-resistant Enterococcus faecalis was successfully treated with ceftaroline and daptomycin. This combination demonstrated excellent synergy in vitro. Mechanistically, ceftaroline enhanced binding of daptomycin to the cell membrane and sensitized E. faecalis to killing by human cathelicidin LL-37, a cationic innate host defense peptide. Daptomycin plus ceftaroline may be considered in salvage therapy in E. faecalis endovascular infections and requires further study.
Study Information
pubmed
2013
2013-05-20T00:00:00.000Z
10.1128/aac.02481-12