Activity of Cathelicidin Peptides against Simkania negevensis.
Donati. Manuela M; Di Francesco. Antonietta A; Di Paolo. Maria M; Fiani. Natascia N; Benincasa. Monica M; Gennaro. Renato R; Nardini. Paola P; Foschi. Claudio C; Cevenini. Roberto R
Key Findings
- LL‑37 showed no activity against Simkania negevensis even at 100 µg/mL
- Other cathelicidins (PG‑1, Bac7, SMAP‑29, BMAP‑27, BMAP‑28) were active at 0.1‑1 µg/mL
- Simkania negevensis is more susceptible to these peptides than chlamydia
Practical Outcomes
- If you’re using LL‑37 supplements hoping for broad antimicrobial protection, this research suggests it won’t help against Simkania negevensis. The other peptides are far more potent, but they’re not widely available as consumer products, so there’s no immediate protocol change.
Summary
The study tested six antimicrobial peptides against the bacteria Simkania negevensis. Five of them worked at very low doses, but the popular peptide LL‑37 did not work even at high doses. This shows LL‑37 isn’t effective against this particular microbe, while other cathelicidins are much stronger.
Abstract
The in vitro activity of six cathelicidin peptides against the reference strain Z of Simkania negevensis was investigated. Five peptides-PG-1, Bac7, SMAP-29, BMAP-27, and BMAP-28-proved to be active at very low concentrations (1 to 0.1 μg/mL), while LL-37 cathelicidin was ineffective even at a concentration of 100 μg/mL. In comparison to chlamydiae, S. negevensis proved to be more susceptible to the antimicrobial peptides tested.
Study Information
pubmed
2011
2011-04-05T00:00:00.000Z
10.1155/2011/708710
1
43