Expression of LL-37, human beta defensin-2, and CCR6 mRNA in patients with psoriasis vulgaris.
Li. Dongsheng D; Li. Jiawen J; Duan. Yiqun Y; Zhou. Xiaoyong X
Key Findings
- LL‑37 mRNA is significantly increased in psoriatic skin lesions
- Human beta‑defensin‑2 (hBD‑2) mRNA is also markedly higher in those lesions
- CCR6 receptor mRNA, which binds hBD‑2, is up‑regulated in psoriasis skin
Practical Outcomes
- The main takeaway for DIY health enthusiasts is that higher natural levels of LL‑37 and hBD‑2 might protect psoriasis‑affected skin from infection, but the paper offers no practical dosing or supplementation advice. Until more human trials are done, it’s best to view this as a mechanistic insight rather than a ready‑to‑apply protocol.
Summary
The study found that people with psoriasis have higher levels of the antimicrobial peptides LL‑37 and hBD‑2, as well as more of the CCR6 receptor, in their skin lesions compared to normal skin. This may explain why psoriasis patients rarely get skin infections, but the research doesn’t tell you how to use or boost these peptides in everyday life.
Abstract
To investigate whether LL-37 and human beta defensin-2 (hBD-2) is related to the patients with psoriasis seldom having skin infections and explore the role of the two peptides and CCR6 (the receptor of hBD-2) in the pathogenesis of psoriasis, the expression levels of mRNA of LL-37, hBD-2, and CCR6 in skin lesions of patients with psoriasis vulgaris were detected by using RT-PCR. The results showed that the mRNA expression levels of the two peptides and CCR6 in psoriatic lesions all increased compared with the normal skin (P<0.001). It was suggested that up-regulated expression of LL-37 and hBD-2 might be the main reason that result in the the skin of patients with psoriasis being seldom infected, and the two peptides and CCR6 might play crucial roles in the pathogenesis of psoriasis.
Study Information
pubmed
2004
10.1007/bf02861879