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LL-37

Cathelicidin, hCAP-18, FALL-39, CAP-18

Quick Stats
Studies 2230
Trials 95
Overview Studies Clinical Trials
Score 2
2003 pubmed

Antimicrobial peptides in the first line defence of human colon mucosa.

Tollin. Maria M; Bergman. Peter P; Svenberg. Torgny T; Jörnvall. Hans H; Gudmundsson. Gudmundur Hrafn GH; Agerberth. Birgitta B

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Key Findings

  • Human colon mucosa produces several antimicrobial peptides, such as ubiquicidin, histone H2B, eosinophil cationic protein, and phospholipase A2.
  • LL-37, along with HNP1-3 and HBD-1, was also detected in the colon tissue.
  • These peptides work together to create a chemical barrier that kills invading microbes.

Practical Outcomes

  • For biohackers, the main takeaway is that the gut’s own defense relies on a cocktail of antimicrobial peptides. While the paper doesn’t give dosing or supplement advice, it supports the idea that strategies to boost natural peptide production (e.g., certain nutrients, probiotics, or lifestyle factors) could help maintain gut barrier health.

Summary

The study shows that the lining of the human colon naturally contains a mix of antimicrobial proteins, including the peptide LL-37, which help kill bacteria and fungi and protect the gut from infection.

Abstract

Antimicrobial peptides and proteins are effector molecules in the protection of epithelial surfaces. We have evaluated the presence of antimicrobial peptides/proteins that can participate in human colonic defence against microbes. A peptide/protein extract of normal human colon mucosa was found to be active against Gram-positive bacteria, Gram-negative bacteria, and fungi. Four polypeptides with antimicrobial activity were isolated from this material and they were identified by N-terminal amino acid sequence analysis as ubiquicidin, histone H2B, eosinophil cationic protein, and phospholipase A(2) (PLA(2)). Using immunodetection and mass spectrometry, LL-37, HNP1-3, and HBD-1 were also identified. Combined, these results indicate that the colon mucosa is protected by a complex mixture of polypeptides, able to kill invading microbes and working in synergy as a barrier against bacterial invasion.

Study Information

Provider

pubmed

Year

2003

DOI

10.1016/s0196-9781(03)00114-1