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MGF Igf-1-ec

IGF-1Ec, IGF-1Eb, Mechano-Growth Factor

Quick Stats
Studies 62
Trials 100
Unknown NA INTERVENTIONAL NCT04638764

Resistance Training in Cardiovascular Disease Patients

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

In this study coronary artery disease patients and patients with heart failure will be randomly assigned to three training groups: combined aerobic interval training with high intensity resistance training, combined aerobic interval training with low intensity resistance training and aerobic interval training.

Detailed Description

Exercise-based cardiac rehabilitation programmes have predominantly used aerobic-dynamic exercise modalities, whereas resistance training have been discouraged in patients with cardiovascular disease, due to safety concerns related to cardiovascular response (heart rate and blood pressure) during the exertion. Contrary to such concerns, recent hemodynamic studies have reported lower blood pressure and heart rate during higher intensity resistance training (\>70 % 1-RM) compared to lower intensity resistance training (\>40 % 1-RM). Furthermore, the latest meta analysis have demonstrated that combined resistance training with standard aerobic interval training has been superior than aerobic training alone in several aspects of health. However, there is still huge heterogeneity in training intervention design, also there still lacks studies to further elucidate the effects of high intensity resistance training combined with aerobic training on physical performance (aerobic capacity, muscle strength, balance), body composition, quality of life, morbidity, mortality, etc. Therefore, the aim of this study was to examine the effects of high (70%-80 % 1-RM) versus low loads (30%- 40 % 1-RM) resistance training in combination with aerobic interval cycling (50 % -80% of baseline peak Power output) in coronary artery disease patients and patients with heart failure.

Interventions

Name: Aerobic interval training combined with high intensity resistance training
Type: OTHER
Description: Patients enrolled in arm of the study will perform 12 weeks of combined aerobic interval training (5 intervals of cycling at the intensity of 50 %-80% of peak power obtained at baseline cardiopulmonary testing) combined with high intensity resistance training (3 sets of leg press at the intensity of 70 %- 80 % of one repetition maximum (1-RM)).
Name: Aerobic interval training combined with low intensity resistance training
Type: OTHER
Description: Patients enrolled in arm of the study will perform 12 weeks of combined aerobic interval training (5 intervals of cycling at the intensity of 50 %-80% of peak power obtained at baseline cardiopulmonary testing) combined with high intensity resistance training (3 sets of leg press at the intensity of 30 %- 40 % 1-RM).
Name: Aerobic interval training
Type: OTHER
Description: Patients enrolled in arm of the study will perform 12 weeks of aerobic interval training (5 intervals of cycling at the intensity of 50 %-80% of peak power obtained at baseline cardiopulmonary testing).

Primary Outcomes

Measure: Change in Maximal aerobic capacity
TimeFrame: Change in maximal aerobic capacity at 12 weeks compared to baseline
Description: Measured as change in VO2 max (ml/kg/min)
Measure: Change in Maximal voluntary contraction of knee extensors
TimeFrame: Change in maximal isometric torque at 12 weeks compared to baseline
Description: Measured as change in maximal isometric torque of knee extensors

Trial Information

NCT ID

NCT04638764

Status

Unknown

Study Type

INTERVENTIONAL

Phases

NA

Sponsor

General Hospital Murska Sobota

Last Updated

December 15, 2025

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